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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.
Venken K, Jacques P, Mortier C, Labadia ME, Decruy T, Coudenys J, Hoyt K, Wayne AL, Hughes R, Turner M, Van Gassen S, Martens L, Smith D, Harcken C, Wahle J, Wang CT, Verheugen E, Schryvers N, Varkas G, Cypers H, Wittoek R, Piette Y, Gyselbrecht L, Van Calenbergh S, Van den Bosch F, Saeys Y, Nabozny G, Elewaut D. Venken K, et al. Among authors: mortier c. Nat Commun. 2019 Jan 2;10(1):9. doi: 10.1038/s41467-018-07911-6. Nat Commun. 2019. PMID: 30602780 Free PMC article.
RORγt inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating γδ-T cells.
Mortier C, Gracey E, Coudenys J, Manuello T, Decruy T, Maelegheer M, Stappers F, Gilis E, Gaublomme D, Van Hoorebeke L, Van Welden S, Ambler C, Hegen M, Symanowicz P, Steyn S, Berstein G, Elewaut D, Venken K. Mortier C, et al. Rheumatology (Oxford). 2023 Sep 1;62(9):3169-3178. doi: 10.1093/rheumatology/kead022. Rheumatology (Oxford). 2023. PMID: 36661300
Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis.
Venken K, Jarlborg M, Decruy T, Mortier C, Vlieghe C, Gilis E, De Craemer AS, Coudenys J, Cambré I, Fleury D, Klimowicz A, Van den Bosch F, Hoorens A, Lobaton T, de Roock S, Sparwasser T, Nabozny G, Jacques P, Elewaut D. Venken K, et al. Among authors: mortier c. Ann Rheum Dis. 2023 Aug;82(8):1076-1090. doi: 10.1136/ard-2022-223757. Epub 2023 May 17. Ann Rheum Dis. 2023. PMID: 37197892
Gut Inflammation in Axial Spondyloarthritis Patients is Characterized by a Marked Type 17 Skewed Mucosal Innate-like T Cell Signature.
Mortier C, Quintelier K, De Craemer AS, Renson T, Deroo L, Dumas E, Verheugen E, Coudenys J, Decruy T, Lukasik Z, Van Gassen S, Saeys Y, Hoorens A, Lobatón T, Van den Bosch F, Van de Wiele T, Venken K, Elewaut D. Mortier C, et al. Arthritis Rheumatol. 2023 Nov;75(11):1969-1982. doi: 10.1002/art.42627. Epub 2023 Oct 4. Arthritis Rheumatol. 2023. PMID: 37293832
27 results