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18 results
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Insights into RNA structure and function from genome-wide studies.
Mortimer SA, Kidwell MA, Doudna JA. Mortimer SA, et al. Nat Rev Genet. 2014 Jul;15(7):469-79. doi: 10.1038/nrg3681. Epub 2014 May 13. Nat Rev Genet. 2014. PMID: 24821474 Review.
Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA.
Lanman RB, Mortimer SA, Zill OA, Sebisanovic D, Lopez R, Blau S, Collisson EA, Divers SG, Hoon DS, Kopetz ES, Lee J, Nikolinakos PG, Baca AM, Kermani BG, Eltoukhy H, Talasaz A. Lanman RB, et al. Among authors: mortimer sa. PLoS One. 2015 Oct 16;10(10):e0140712. doi: 10.1371/journal.pone.0140712. eCollection 2015. PLoS One. 2015. PMID: 26474073 Free PMC article.
Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients.
Kim ST, Lee WS, Lanman RB, Mortimer S, Zill OA, Kim KM, Jang KT, Kim SH, Park SH, Park JO, Park YS, Lim HY, Eltoukhy H, Kang WK, Lee WY, Kim HC, Park K, Lee J, Talasaz A. Kim ST, et al. Oncotarget. 2015 Nov 24;6(37):40360-9. doi: 10.18632/oncotarget.5465. Oncotarget. 2015. PMID: 26452027 Free PMC article. Clinical Trial.
Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution.
Mortimer SA, Weeks KM. Mortimer SA, et al. Nat Protoc. 2009;4(10):1413-21. doi: 10.1038/nprot.2009.126. Epub 2009 Sep 10. Nat Protoc. 2009. PMID: 19745823 Free PMC article.
Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.
Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate JH. Sun C, et al. Among authors: mortimer sa. Nucleic Acids Res. 2013 Aug;41(15):7512-21. doi: 10.1093/nar/gkt510. Epub 2013 Jun 13. Nucleic Acids Res. 2013. PMID: 23766293 Free PMC article.
SHAPE-Seq: High-Throughput RNA Structure Analysis.
Mortimer SA, Trapnell C, Aviran S, Pachter L, Lucks JB. Mortimer SA, et al. Curr Protoc Chem Biol. 2012 Dec 1;4(4):275-97. doi: 10.1002/9780470559277.ch120019. Curr Protoc Chem Biol. 2012. PMID: 23788555
Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure.
Mortimer SA, Doudna JA. Mortimer SA, et al. Nucleic Acids Res. 2013 Apr;41(7):4230-40. doi: 10.1093/nar/gkt075. Epub 2013 Feb 14. Nucleic Acids Res. 2013. PMID: 23416544 Free PMC article.
Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning.
Berry KE, Waghray S, Mortimer SA, Bai Y, Doudna JA. Berry KE, et al. Among authors: mortimer sa. Structure. 2011 Oct 12;19(10):1456-66. doi: 10.1016/j.str.2011.08.002. Structure. 2011. PMID: 22000514 Free PMC article.
Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq).
Lucks JB, Mortimer SA, Trapnell C, Luo S, Aviran S, Schroth GP, Pachter L, Doudna JA, Arkin AP. Lucks JB, et al. Among authors: mortimer sa. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11063-8. doi: 10.1073/pnas.1106501108. Epub 2011 Jun 3. Proc Natl Acad Sci U S A. 2011. PMID: 21642531 Free PMC article.
Modeling and automation of sequencing-based characterization of RNA structure.
Aviran S, Trapnell C, Lucks JB, Mortimer SA, Luo S, Schroth GP, Doudna JA, Arkin AP, Pachter L. Aviran S, et al. Among authors: mortimer sa. Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11069-74. doi: 10.1073/pnas.1106541108. Epub 2011 Jun 3. Proc Natl Acad Sci U S A. 2011. PMID: 21642536 Free PMC article.
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