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NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.
Nicholls AW, Mortishire-Smith RJ, Nicholson JK. Nicholls AW, et al. Chem Res Toxicol. 2003 Nov;16(11):1395-404. doi: 10.1021/tx0340293. Chem Res Toxicol. 2003. PMID: 14615964
Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe.
Griffin JL, Nicholls AW, Keun HC, Mortishire-Smith RJ, Nicholson JK, Kuehn T. Griffin JL, et al. Analyst. 2002 May;127(5):582-4. doi: 10.1039/b201207c. Analyst. 2002. PMID: 12081031
Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.
Mortishire-Smith RJ, Skiles GL, Lawrence JW, Spence S, Nicholls AW, Johnson BA, Nicholson JK. Mortishire-Smith RJ, et al. Chem Res Toxicol. 2004 Feb;17(2):165-73. doi: 10.1021/tx034123j. Chem Res Toxicol. 2004. PMID: 14967004
A proteomic investigation of drug-induced steatosis in rat liver.
Meneses-Lorente G, Guest PC, Lawrence J, Muniappa N, Knowles MR, Skynner HA, Salim K, Cristea I, Mortishire-Smith R, Gaskell SJ, Watt A. Meneses-Lorente G, et al. Chem Res Toxicol. 2004 May;17(5):605-12. doi: 10.1021/tx034203n. Chem Res Toxicol. 2004. PMID: 15144217
1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.
Herbert RH, Gerhard U, Mortishire-Smith RJ, Thomas SR, Hollingworth G. Herbert RH, et al. Magn Reson Chem. 2005 Aug;43(8):658-61. doi: 10.1002/mrc.1604. Magn Reson Chem. 2005. PMID: 15924294
Metabolite identification in drug discovery.
Watt AP, Mortishire-Smith RJ, Gerhard U, Thomas SR. Watt AP, et al. Curr Opin Drug Discov Devel. 2003 Jan;6(1):57-65. Curr Opin Drug Discov Devel. 2003. PMID: 12613277 Review.
Synthesis and conformational dynamics of tricyclic pyridones containing a fused seven-membered ring.
Gibson KR, Hitzel L, Mortishire-Smith RJ, Gerhard U, Jelley RA, Reeve AJ, Rowley M, Nadin A, Owens AP. Gibson KR, et al. J Org Chem. 2002 Dec 27;67(26):9354-60. doi: 10.1021/jo026411a. J Org Chem. 2002. PMID: 12492338
Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep.
Pears MR, Salek RM, Palmer DN, Kay GW, Mortishire-Smith RJ, Griffin JL. Pears MR, et al. J Neurosci Res. 2007 Nov 15;85(15):3494-504. doi: 10.1002/jnr.21343. J Neurosci Res. 2007. PMID: 17510975
The toxicity in vitro of beta-amyloid protein.
Iversen LL, Mortishire-Smith RJ, Pollack SJ, Shearman MS. Iversen LL, et al. Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):1-16. doi: 10.1042/bj3110001. Biochem J. 1995. PMID: 7575439 Free PMC article. Review. No abstract available.
A functional analysis of mouse models of cardiac disease through metabolic profiling.
Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace AA, Clarke K, Griffin JL. Jones GL, et al. J Biol Chem. 2005 Mar 4;280(9):7530-9. doi: 10.1074/jbc.M410200200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546876
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