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Unveiling the role of network and systems biology in drug discovery.
Pujol A, Mosca R, Farrés J, Aloy P. Pujol A, et al. Among authors: mosca r. Trends Pharmacol Sci. 2010 Mar;31(3):115-23. doi: 10.1016/j.tips.2009.11.006. Epub 2010 Feb 1. Trends Pharmacol Sci. 2010. PMID: 20117850 Review.
Towards a detailed atlas of protein-protein interactions.
Mosca R, Pons T, Céol A, Valencia A, Aloy P. Mosca R, et al. Curr Opin Struct Biol. 2013 Dec;23(6):929-40. doi: 10.1016/j.sbi.2013.07.005. Epub 2013 Jul 26. Curr Opin Struct Biol. 2013. PMID: 23896349 Review.
Structural systems pharmacology: the role of 3D structures in next-generation drug development.
Duran-Frigola M, Mosca R, Aloy P. Duran-Frigola M, et al. Among authors: mosca r. Chem Biol. 2013 May 23;20(5):674-84. doi: 10.1016/j.chembiol.2013.03.004. Chem Biol. 2013. PMID: 23706634 Review.
Three-dimensional modeling of protein interactions and complexes is going 'omics.
Stein A, Mosca R, Aloy P. Stein A, et al. Among authors: mosca r. Curr Opin Struct Biol. 2011 Apr;21(2):200-8. doi: 10.1016/j.sbi.2011.01.005. Epub 2011 Feb 12. Curr Opin Struct Biol. 2011. PMID: 21320770 Review.
Pushing structural information into the yeast interactome by high-throughput protein docking experiments.
Mosca R, Pons C, Fernández-Recio J, Aloy P. Mosca R, et al. PLoS Comput Biol. 2009 Aug;5(8):e1000490. doi: 10.1371/journal.pcbi.1000490. Epub 2009 Aug 28. PLoS Comput Biol. 2009. PMID: 19714207 Free PMC article.
The role of structural disorder in the rewiring of protein interactions through evolution.
Mosca R, Pache RA, Aloy P. Mosca R, et al. Mol Cell Proteomics. 2012 Jul;11(7):M111.014969. doi: 10.1074/mcp.M111.014969. Epub 2012 Mar 2. Mol Cell Proteomics. 2012. PMID: 22389433 Free PMC article.
Residues Coevolution Guides the Systematic Identification of Alternative Functional Conformations in Proteins.
Sfriso P, Duran-Frigola M, Mosca R, Emperador A, Aloy P, Orozco M. Sfriso P, et al. Among authors: mosca r. Structure. 2016 Jan 5;24(1):116-126. doi: 10.1016/j.str.2015.10.025. Epub 2015 Dec 10. Structure. 2016. PMID: 26688214
Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli.
Kumar A, Beloglazova N, Bundalovic-Torma C, Phanse S, Deineko V, Gagarinova A, Musso G, Vlasblom J, Lemak S, Hooshyar M, Minic Z, Wagih O, Mosca R, Aloy P, Golshani A, Parkinson J, Emili A, Yakunin AF, Babu M. Kumar A, et al. Among authors: mosca r. Cell Rep. 2016 Jan 26;14(3):648-661. doi: 10.1016/j.celrep.2015.12.060. Epub 2016 Jan 8. Cell Rep. 2016. PMID: 26774489
Interactome3D: adding structural details to protein networks.
Mosca R, Céol A, Aloy P. Mosca R, et al. Nat Methods. 2013 Jan;10(1):47-53. doi: 10.1038/nmeth.2289. Epub 2012 Dec 16. Nat Methods. 2013. PMID: 23399932
Assessing the applicability of template-based protein docking in the twilight zone.
Negroni J, Mosca R, Aloy P. Negroni J, et al. Among authors: mosca r. Structure. 2014 Sep 2;22(9):1356-1362. doi: 10.1016/j.str.2014.07.009. Epub 2014 Aug 21. Structure. 2014. PMID: 25156427
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