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LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice.
Faggioni R, Fuller J, Moser A, Feingold KR, Grunfeld C. Faggioni R, et al. Among authors: moser a. Am J Physiol. 1997 Jul;273(1 Pt 2):R181-6. doi: 10.1152/ajpregu.1997.273.1.R181. Am J Physiol. 1997. PMID: 9249548
As might be predicted if leptin had a role in anorexia, the db/db mice were somewhat resistant to LPS-induced anorexia. However the ob/ob mice were more sensitive to LPS-induced anorexia. ...
As might be predicted if leptin had a role in anorexia, the db/db mice were somewhat resistant to LPS-induced anorexia. However the o …
Mechanisms of triglyceride accumulation in activated macrophages.
Feingold KR, Shigenaga JK, Kazemi MR, McDonald CM, Patzek SM, Cross AS, Moser A, Grunfeld C. Feingold KR, et al. Among authors: moser a. J Leukoc Biol. 2012 Oct;92(4):829-39. doi: 10.1189/jlb.1111537. Epub 2012 Jun 29. J Leukoc Biol. 2012. PMID: 22753953 Free PMC article.
FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis.
Feingold KR, Grunfeld C, Heuer JG, Gupta A, Cramer M, Zhang T, Shigenaga JK, Patzek SM, Chan ZW, Moser A, Bina H, Kharitonenkov A. Feingold KR, et al. Among authors: moser a. Endocrinology. 2012 Jun;153(6):2689-700. doi: 10.1210/en.2011-1496. Epub 2012 Apr 2. Endocrinology. 2012. PMID: 22474187 Free PMC article.
Fibroblast growth factor 21 (FGF21) is a recently discovered hormone that regulates lipid and glucose metabolism and stimulates ketogenesis. ...Thus, FGF21 is a positive APR protein that protects animals from the toxic effects of LPS and sepsis....
Fibroblast growth factor 21 (FGF21) is a recently discovered hormone that regulates lipid and glucose metabolism and stimulates ketog …
Inflammation inhibits GPR81 expression in adipose tissue.
Feingold KR, Moser A, Shigenaga JK, Grunfeld C. Feingold KR, et al. Among authors: moser a. Inflamm Res. 2011 Oct;60(10):991-5. doi: 10.1007/s00011-011-0361-2. Epub 2011 Jul 13. Inflamm Res. 2011. PMID: 21751047
RESULTS: LPS resulted in a marked decrease in GPR81 mRNA level in mouse adipose tissue in C57BL/6 and OuJ mice, an effect that was not observed in HeJ mice, which have a mutation in TLR4. ...
RESULTS: LPS resulted in a marked decrease in GPR81 mRNA level in mouse adipose tissue in C57BL/6 and OuJ mice, an effect that was no …
Inflammation inhibits the expression of phosphoenolpyruvate carboxykinase in liver and adipose tissue.
Feingold KR, Moser A, Shigenaga JK, Grunfeld C. Feingold KR, et al. Among authors: moser a. Innate Immun. 2012 Apr;18(2):231-40. doi: 10.1177/1753425911398678. Epub 2011 Mar 30. Innate Immun. 2012. PMID: 21450790
Triglyceride biosynthesis requires glycerol 3-phosphate and phosphoenolpyruvate carboxykinase (PEPCK) plays a key role. We demonstrate that LPS, zymosan, and TNF-α decrease PEPCK in liver and fat. ...Lipopolysaccharide and zymosan reduce PPARγ and RXRα expression in fat, s …
Triglyceride biosynthesis requires glycerol 3-phosphate and phosphoenolpyruvate carboxykinase (PEPCK) plays a key role. We demonstrat …
Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
Feingold KR, Shigenaga JK, Patzek SM, Chui LG, Moser A, Grunfeld C. Feingold KR, et al. Among authors: moser a. Innate Immun. 2011 Apr;17(2):174-82. doi: 10.1177/1753425909357578. Epub 2010 Jan 25. Innate Immun. 2011. PMID: 20100709
Here, we demonstrate that lipopolysaccharide (LPS) treatment causes a marked decrease in ChREBP mRNA and protein levels in the liver of mice fed a normal chow diet or in mice fasted for 24 h and then re-fed a high carbohydrate diet. This decrease occurs rapid …
Here, we demonstrate that lipopolysaccharide (LPS) treatment causes a marked decrease in ChREBP mRNA and protein levels in the liver …
Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm.
Feingold KR, Moser A, Patzek SM, Shigenaga JK, Grunfeld C. Feingold KR, et al. Among authors: moser a. J Lipid Res. 2009 Oct;50(10):2055-63. doi: 10.1194/jlr.M800655-JLR200. Epub 2009 May 14. J Lipid Res. 2009. PMID: 19443862 Free PMC article.
Respiratory failure is a major cause of mortality during septic shock and is due in part to decreased ventilatory muscle contraction. ...Finally, in PPARalpha deficient mice, baseline CPT-1beta and FATP-1 levels were markedly decreased and were not further reduced by LPS s …
Respiratory failure is a major cause of mortality during septic shock and is due in part to decreased ventilatory muscle contraction. …
Tumor necrosis factor and interleukin 1 decrease RXRalpha, PPARalpha, PPARgamma, LXRalpha, and the coactivators SRC-1, PGC-1alpha, and PGC-1beta in liver cells.
Kim MS, Sweeney TR, Shigenaga JK, Chui LG, Moser A, Grunfeld C, Feingold KR. Kim MS, et al. Among authors: moser a. Metabolism. 2007 Feb;56(2):267-79. doi: 10.1016/j.metabol.2006.10.007. Metabolism. 2007. PMID: 17224343 Free PMC article.
During the acute phase response, cytokines induce marked alterations in lipid metabolism including an increase in serum triglyceride levels and a decrease in hepatic fatty acid oxidation, in bile acid synthesis, and in high-density lipoprotein levels. ...Finally, using con …
During the acute phase response, cytokines induce marked alterations in lipid metabolism including an increase in serum triglyceride levels …
Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response.
Kim MS, Shigenaga J, Moser A, Grunfeld C, Feingold KR. Kim MS, et al. Among authors: moser a. Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E731-8. doi: 10.1152/ajpendo.00130.2004. Epub 2004 Jun 15. Am J Physiol Endocrinol Metab. 2004. PMID: 15198932
We found that mRNA levels of Sult2A1 decrease in a time- and dose-dependent manner during the LPS-induced APR. Similar changes were observed in the mRNA levels of PAPSS2, the major synthase of PAPS in the liver. ...Our study provides a possible mechanism by which in …
We found that mRNA levels of Sult2A1 decrease in a time- and dose-dependent manner during the LPS-induced APR. Similar changes were o …
Repression of farnesoid X receptor during the acute phase response.
Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C. Kim MS, et al. Among authors: moser a. J Biol Chem. 2003 Mar 14;278(11):8988-95. doi: 10.1074/jbc.M212633200. Epub 2003 Jan 7. J Biol Chem. 2003. PMID: 12519762
Importantly, TNF and IL-1 almost completely blocked the expression of luciferase activity linked to a FXR response element promoter construct transfected into Hep3B cells. ...
Importantly, TNF and IL-1 almost completely blocked the expression of luciferase activity linked to a FXR response element promoter c …
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