Motabar O - Search Results

1

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Marugan JJ, et al. Among authors: motabar o. J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20. J Med Chem. 2011. PMID: 21250698 Free PMC article.

2

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Sidransky E, Aungst RA, Liu K, Sadhukhan SK, Austin CP. Marugan JJ, et al. Among authors: motabar o. Eur J Med Chem. 2010 May;45(5):1880-97. doi: 10.1016/j.ejmech.2010.01.027. Epub 2010 Feb 1. Eur J Med Chem. 2010. PMID: 20206419 Free PMC article.

3

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.

Motabar O, Goldin E, Leister W, Liu K, Southall N, Huang W, Marugan JJ, Sidransky E, Zheng W. Motabar O, et al. Anal Bioanal Chem. 2012 Jan;402(2):731-9. doi: 10.1007/s00216-011-5496-z. Epub 2011 Oct 28. Anal Bioanal Chem. 2012. PMID: 22033823 Free PMC article.

4

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.

Goldin E, Zheng W, Motabar O, Southall N, Choi JH, Marugan J, Austin CP, Sidransky E. Goldin E, et al. Among authors: motabar o. PLoS One. 2012;7(1):e29861. doi: 10.1371/journal.pone.0029861. Epub 2012 Jan 17. PLoS One. 2012. PMID: 22272254 Free PMC article.

5

Non-iminosugar glucocerebrosidase small molecule chaperones.

Marugan JJ, Huang W, Motabar O, Zheng W, Xiao J, Patnaik S, Southall N, Westbroek W, Lea WA, Simeonov A, Goldin E, Debernardi MA, Sidransky E. Marugan JJ, et al. Among authors: motabar o. Medchemcomm. 2012 Jan;3(1):56-60. doi: 10.1039/C1MD00200G. Epub 2011 Oct 24. Medchemcomm. 2012. PMID: 22606365 Free PMC article.

6

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.

Patnaik S, Zheng W, Choi JH, Motabar O, Southall N, Westbroek W, Lea WA, Velayati A, Goldin E, Sidransky E, Leister W, Marugan JJ. Patnaik S, et al. Among authors: motabar o. J Med Chem. 2012 Jun 28;55(12):5734-48. doi: 10.1021/jm300063b. Epub 2012 Jun 8. J Med Chem. 2012. PMID: 22646221 Free PMC article.

7

Discovery of a novel noniminosugar acid α glucosidase chaperone series.

Xiao J, Westbroek W, Motabar O, Lea WA, Hu X, Velayati A, Zheng W, Southall N, Gustafson AM, Goldin E, Sidransky E, Liu K, Simeonov A, Tamargo RJ, Ribes A, Matalonga L, Ferrer M, Marugan JJ. Xiao J, et al. Among authors: motabar o. J Med Chem. 2012 Sep 13;55(17):7546-59. doi: 10.1021/jm3005543. Epub 2012 Aug 17. J Med Chem. 2012. PMID: 22834902 Free PMC article.

8

A new resorufin-based alpha-glucosidase assay for high-throughput screening.

Motabar O, Shi ZD, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Motabar O, et al. Anal Biochem. 2009 Jul 1;390(1):79-84. doi: 10.1016/j.ab.2009.04.010. Epub 2009 Apr 14. Anal Biochem. 2009. PMID: 19371716 Free PMC article.

9

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase.

Shi ZD, Motabar O, Goldin E, Liu K, Southall N, Sidransky E, Austin CP, Griffiths GL, Zheng W. Shi ZD, et al. Among authors: motabar o. Anal Bioanal Chem. 2009 Aug;394(7):1903-9. doi: 10.1007/s00216-009-2879-5. Epub 2009 Jun 13. Anal Bioanal Chem. 2009. PMID: 19521690 Free PMC article.

10

Fabry disease - current treatment and new drug development.

Motabar O, Sidransky E, Goldin E, Zheng W. Motabar O, et al. Curr Chem Genomics. 2010 Jul 23;4:50-6. doi: 10.2174/1875397301004010050. Curr Chem Genomics. 2010. PMID: 21127742 Free PMC article.

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