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Primary explants of human uroepithelium show an unusual response to low-dose irradiation with cobalt-60 gamma rays.
Mothersill C, Harney J, Lyng F, Cottell D, Parsons K, Murphy DM, Seymour CB. Mothersill C, et al. Radiat Res. 1995 May;142(2):181-7. Radiat Res. 1995. PMID: 7724733
Oncoprotein (p53, c-myc, bcl-2, p21 ras) and EGFR expression were also measured in these cultures and were significantly increased. ...
Oncoprotein (p53, c-myc, bcl-2, p21 ras) and EGFR expression were also measured in these cultures and were significantly increased. . …
High levels of stable p53 protein and the expression of c-myc in cultured human epithelial tissue after cobalt-60 irradiation.
Mothersill C, Seymour CB, Harney J, Hennessy TP. Mothersill C, et al. Radiat Res. 1994 Mar;137(3):317-22. Radiat Res. 1994. PMID: 8146274
These foci have previously been shown to be c-myc positive and to have an abnormal, tumor-like ultrastructure. Expression of c-myc and the level of stable p53 proteins have now been examined in these cultures 2 weeks after irradiation. ...Cells positive for p53 were …
These foci have previously been shown to be c-myc positive and to have an abnormal, tumor-like ultrastructure. Expression of c
Induction of stable p53 oncoprotein and of c-myc overexpression in cultured normal human uroepithelium by radiation and N-nitrosodiethanolamine.
Mothersill C, Harney J, Seymour CB. Mothersill C, et al. Radiat Res. 1994 Apr;138(1):93-8. Radiat Res. 1994. PMID: 8146306
In these cultures, c-myc expression was confined to viable, normal-appearing cells at the growing edge of the culture and to apoptotic bodies. ...The c-myc protein was overexpressed in all cultures with abnormal p53. It would appear that elevated expression of confo …
In these cultures, c-myc expression was confined to viable, normal-appearing cells at the growing edge of the culture and to apoptoti …
Persistent expression of morphological abnormalities in the distant progeny of irradiated cells.
Lyng FM, O'Reilly S, Cottell DC, Seymour CB, Mothersill C. Lyng FM, et al. Among authors: mothersill c. Radiat Environ Biophys. 1996 Nov;35(4):273-83. doi: 10.1007/s004110050040. Radiat Environ Biophys. 1996. PMID: 9008004
Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to low-dose gamma-radiation.
Colucci S, Mothersill C, Harney J, Gamble SC, Seymour C, Arrand JE. Colucci S, et al. Among authors: mothersill c. Int J Radiat Biol. 1997 Jul;72(1):21-31. doi: 10.1080/095530097143509. Int J Radiat Biol. 1997. PMID: 9246191
C-myc, Bcl-2 and stable p53 proteins were found to be elevated in cultures following both radiation doses. PCR-SSCPE analysis of the p53 gene was performed on cultures in order to determine whether genetic mutations could be the underlying basis for persistent increased st
C-myc, Bcl-2 and stable p53 proteins were found to be elevated in cultures following both radiation doses. PCR-SSCPE analysis of the
Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment.
Seymour CB, Mothersill C. Seymour CB, et al. Among authors: mothersill c. Radiat Oncol Investig. 1997;5(3):106-10. doi: 10.1002/(SICI)1520-6823(1997)5:3<106::AID-ROI4>3.0.CO;2-1. Radiat Oncol Investig. 1997. PMID: 9303065
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