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Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
Rottiers V, Motola DL, Gerisch B, Cummins CL, Nishiwaki K, Mangelsdorf DJ, Antebi A. Rottiers V, et al. Among authors: motola dl. Dev Cell. 2006 Apr;10(4):473-82. doi: 10.1016/j.devcel.2006.02.008. Epub 2006 Mar 23. Dev Cell. 2006. PMID: 16563875
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
Wollam J, Magomedova L, Magner DB, Shen Y, Rottiers V, Motola DL, Mangelsdorf DJ, Cummins CL, Antebi A. Wollam J, et al. Among authors: motola dl. Aging Cell. 2011 Oct;10(5):879-84. doi: 10.1111/j.1474-9726.2011.00733.x. Epub 2011 Aug 7. Aging Cell. 2011. PMID: 21749634 Free PMC article.
Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor.
Sharma KK, Wang Z, Motola DL, Cummins CL, Mangelsdorf DJ, Auchus RJ. Sharma KK, et al. Among authors: motola dl. Mol Endocrinol. 2009 May;23(5):640-8. doi: 10.1210/me.2008-0415. Epub 2009 Feb 5. Mol Endocrinol. 2009. PMID: 19196833 Free PMC article.
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling.
Gerisch B, Rottiers V, Li D, Motola DL, Cummins CL, Lehrach H, Mangelsdorf DJ, Antebi A. Gerisch B, et al. Among authors: motola dl. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5014-9. doi: 10.1073/pnas.0700847104. Epub 2007 Mar 14. Proc Natl Acad Sci U S A. 2007. PMID: 17360327 Free PMC article.
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Motola DL, Cummins CL, Rottiers V, Sharma KK, Li T, Li Y, Suino-Powell K, Xu HE, Auchus RJ, Antebi A, Mangelsdorf DJ. Motola DL, et al. Cell. 2006 Mar 24;124(6):1209-23. doi: 10.1016/j.cell.2006.01.037. Epub 2006 Mar 9. Cell. 2006. PMID: 16529801
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes.
Wang Z, Zhou XE, Motola DL, Gao X, Suino-Powell K, Conneely A, Ogata C, Sharma KK, Auchus RJ, Lok JB, Hawdon JM, Kliewer SA, Xu HE, Mangelsdorf DJ. Wang Z, et al. Among authors: motola dl. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9138-43. doi: 10.1073/pnas.0904064106. Epub 2009 Jun 2. Proc Natl Acad Sci U S A. 2009. PMID: 19497877 Free PMC article.
De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase.
Cheng JB, Motola DL, Mangelsdorf DJ, Russell DW. Cheng JB, et al. Among authors: motola dl. J Biol Chem. 2003 Sep 26;278(39):38084-93. doi: 10.1074/jbc.M307028200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12867411 Free PMC article.
Structural conservation of ligand binding reveals a bile acid-like signaling pathway in nematodes.
Zhi X, Zhou XE, Melcher K, Motola DL, Gelmedin V, Hawdon J, Kliewer SA, Mangelsdorf DJ, Xu HE. Zhi X, et al. Among authors: motola dl. J Biol Chem. 2012 Feb 10;287(7):4894-903. doi: 10.1074/jbc.M111.315242. Epub 2011 Dec 14. J Biol Chem. 2012. PMID: 22170062 Free PMC article.
Oligomerization and regulated proteolytic processing of angiopoietin-like protein 4.
Ge H, Yang G, Huang L, Motola DL, Pourbahrami T, Li C. Ge H, et al. Among authors: motola dl. J Biol Chem. 2004 Jan 16;279(3):2038-45. doi: 10.1074/jbc.M307583200. Epub 2003 Oct 21. J Biol Chem. 2004. PMID: 14570927
A TALEN genome-editing system for generating human stem cell-based disease models.
Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. Ding Q, et al. Among authors: motola dl. Cell Stem Cell. 2013 Feb 7;12(2):238-51. doi: 10.1016/j.stem.2012.11.011. Epub 2012 Dec 13. Cell Stem Cell. 2013. PMID: 23246482 Free PMC article.
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