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Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.
Jeon AH, Böhm C, Chen F, Huo H, Ruan X, Ren CH, Ho K, Qamar S, Mathews PM, Fraser PE, Mount HT, St George-Hyslop P, Schmitt-Ulms G. Jeon AH, et al. Among authors: mount ht. J Biol Chem. 2013 May 24;288(21):15352-66. doi: 10.1074/jbc.M112.441840. Epub 2013 Apr 15. J Biol Chem. 2013. PMID: 23589300 Free PMC article.
Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.
Francis BM, Kim J, Barakat ME, Fraenkl S, Yücel YH, Peng S, Michalski B, Fahnestock M, McLaurin J, Mount HT. Francis BM, et al. Among authors: mount ht. Neurobiol Aging. 2012 Mar;33(3):555-63. doi: 10.1016/j.neurobiolaging.2010.04.003. Epub 2010 May 5. Neurobiol Aging. 2012. PMID: 20447730 Free PMC article.
Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins.
Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, Fraser PE. Yang DS, et al. Among authors: mount ht. J Biol Chem. 2002 Aug 2;277(31):28135-42. doi: 10.1074/jbc.M110871200. Epub 2002 May 24. J Biol Chem. 2002. PMID: 12032140 Free article.
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Chen F, et al. Among authors: mount ht. J Biol Chem. 2003 May 30;278(22):19974-9. doi: 10.1074/jbc.M210049200. Epub 2003 Mar 18. J Biol Chem. 2003. PMID: 12646573 Free article.
65 results