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Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.
Davies A, Jordanides NE, Giannoudis A, Lucas CM, Hatziieremia S, Harris RJ, Jørgensen HG, Holyoake TL, Pirmohamed M, Clark RE, Mountford JC. Davies A, et al. Among authors: mountford jc. Leukemia. 2009 Nov;23(11):1999-2006. doi: 10.1038/leu.2009.166. Epub 2009 Aug 27. Leukemia. 2009. PMID: 19710702 Free article.
Punish the parent not the progeny.
Elrick LJ, Jorgensen HG, Mountford JC, Holyoake TL. Elrick LJ, et al. Among authors: mountford jc. Blood. 2005 Mar 1;105(5):1862-6. doi: 10.1182/blood-2004-08-3373. Epub 2004 Nov 4. Blood. 2005. PMID: 15528314 Free article. Review.
Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells.
Myssina S, Helgason GV, Serrels A, Jørgensen HG, Bhatia R, Modi H, Baird JW, Mountford JC, Hamilton A, Schemionek M, Koschmieder S, Brunton VG, Holyoake TL. Myssina S, et al. Among authors: mountford jc. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18. Exp Hematol. 2009. PMID: 19100678 Free article.
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