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Photo-induced covalent attachment of agonists as a tool to study allosteric mechanisms of nicotinic acetylcholine receptors.
Mourot A, Kotzyba-Hibert F, Goeldner M, Bamberg E. Mourot A, et al. J Mol Neurosci. 2006;30(1-2):3-4. doi: 10.1385/JMN:30:1:3. J Mol Neurosci. 2006. PMID: 17192602
In the dark, AC5 (see structure below) evokes robust currents on oocytes expressing Torpedo nAChR, displaying maximal amplitude comparable to ACh, with EC50 = 1.2 microM (Mourot et al., 2005). When the voltage-clamp oocyte was exposed to UV light in the presence of 30 micr …
In the dark, AC5 (see structure below) evokes robust currents on oocytes expressing Torpedo nAChR, displaying maximal amplitude comparable t …
Measuring ion channels on solid supported membranes.
Schulz P, Dueck B, Mourot A, Hatahet L, Fendler K. Schulz P, et al. Among authors: mourot a. Biophys J. 2009 Jul 8;97(1):388-96. doi: 10.1016/j.bpj.2009.04.022. Biophys J. 2009. PMID: 19580777 Free PMC article.
Photochromic blockers of voltage-gated potassium channels.
Banghart MR, Mourot A, Fortin DL, Yao JZ, Kramer RH, Trauner D. Banghart MR, et al. Among authors: mourot a. Angew Chem Int Ed Engl. 2009;48(48):9097-101. doi: 10.1002/anie.200904504. Angew Chem Int Ed Engl. 2009. PMID: 19882609 Free PMC article. No abstract available.
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