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Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.
Mousa A, Naderpoor N, Teede H, Scragg R, de Courten B. Mousa A, et al. Nutr Rev. 2018 May 1;76(5):380-394. doi: 10.1093/nutrit/nux077. Nutr Rev. 2018. PMID: 29490085
In meta-analyses of 20 RCTs (n = 1270 participants), vitamin D-supplemented groups had lower levels of C-reactive protein (standardized mean difference [SMD] -0.23; 95%CI, -0.37 to -0.09; P = 0.002) and tumor necrosis factor α (SMD -0.49; 95%CI, -0.84 to -0.15; P = 0.005), a
In meta-analyses of 20 RCTs (n = 1270 participants), vitamin D-supplemented groups had lower levels of C-reactive protein (standardized mean …
Vitamin D and cardiometabolic risk factors and diseases.
Mousa A, Naderpoor N, Teede HJ, De Courten MP, Scragg R, De Courten B. Mousa A, et al. Minerva Endocrinol. 2015 Sep;40(3):213-30. Epub 2015 Feb 25. Minerva Endocrinol. 2015. PMID: 25714787 Review.
Insulin resistance, which is a shared feature in these conditions, is also strongly linked to the development of polycystic ovary syndrome (PCOS), which is the most common endocrine disease in women of reproductive age and a major cause of infertility. ...Treating v …
Insulin resistance, which is a shared feature in these conditions, is also strongly linked to the development of polycystic ovary syn …
Vitamin D supplementation for the prevention of type 2 diabetes in overweight adults: study protocol for a randomized controlled trial.
de Courten B, Mousa A, Naderpoor N, Teede H, de Courten MP, Scragg R. de Courten B, et al. Among authors: mousa a. Trials. 2015 Aug 7;16:335. doi: 10.1186/s13063-015-0851-6. Trials. 2015. PMID: 26246241 Free PMC article. Clinical Trial.
A secondary aim is to determine whether these relationships are mediated by a reduction in underlying subclinical inflammation associated with obesity. ...The intervention group will receive a first dose of 100,000 IU followed by 4,000 IU vitamin D (cholecalc
A secondary aim is to determine whether these relationships are mediated by a reduction in underlying subclinical inflammation
Effect of vitamin D supplementation on inflammation: protocol for a systematic review.
Mousa A, Misso M, Teede H, Scragg R, de Courten B. Mousa A, et al. BMJ Open. 2016 Apr 5;6(4):e010804. doi: 10.1136/bmjopen-2015-010804. BMJ Open. 2016. PMID: 27048637 Free PMC article.
This systematic review will identify potential clinical implications of vitamin D deficiency and supplementation, and will be disseminated through a peer-reviewed publication and at conference meetings, to inform future research on the efficacy of vitamin D supplementation …
This systematic review will identify potential clinical implications of vitamin D deficiency and supplementation, and will be disseminated t …
Vitamin D in Reproductive Health and Pregnancy.
Mousa A, Abell S, Scragg R, de Courten B. Mousa A, et al. Semin Reprod Med. 2016 Mar;34(2):e1-13. doi: 10.1055/s-0036-1583529. Epub 2016 May 26. Semin Reprod Med. 2016. PMID: 27228115 Review.
Emerging evidence suggests that vitamin D may have a plethora of other functions including cardiometabolic and immunological effects and a role in modulating human reproductive processes. ...While these studies indicate that VDD may be a risk factor for adver …
Emerging evidence suggests that vitamin D may have a plethora of other functions including cardiometabolic and immunological effects …
Serum 25-hydroxyvitamin D concentration is not associated with glomerular filtration rate in a predominantly obese otherwise healthy population.
Naderpoor N, Mousa A, de Courten MPJ, Scragg R, Ranasinha S, de Courten B. Naderpoor N, et al. Among authors: mousa a. J Steroid Biochem Mol Biol. 2017 Oct;173:253-257. doi: 10.1016/j.jsbmb.2016.09.019. Epub 2016 Sep 28. J Steroid Biochem Mol Biol. 2017. PMID: 27687738
Evidence from observational studies indicates a role for vitamin D in kidney function and progression to chronic kidney disease. ...We examined the relationship between 25(OH)D and estimated glomerular filtration rate (eGFR) in a predominantly obese otherwise health …
Evidence from observational studies indicates a role for vitamin D in kidney function and progression to chronic kidney disease. ...W …
25-hydroxyvitamin D is associated with adiposity and cardiometabolic risk factors in a predominantly vitamin D-deficient and overweight/obese but otherwise healthy cohort.
Mousa A, Naderpoor N, de Courten MPJ, Scragg R, de Courten B. Mousa A, et al. J Steroid Biochem Mol Biol. 2017 Oct;173:258-264. doi: 10.1016/j.jsbmb.2016.12.008. Epub 2016 Dec 19. J Steroid Biochem Mol Biol. 2017. PMID: 28007531
Vitamin D supplementation has no effect on insulin sensitivity or secretion in vitamin D-deficient, overweight or obese adults: a randomized placebo-controlled trial.
Mousa A, Naderpoor N, de Courten MP, Teede H, Kellow N, Walker K, Scragg R, de Courten B. Mousa A, et al. Am J Clin Nutr. 2017 Jun;105(6):1372-1381. doi: 10.3945/ajcn.117.152736. Epub 2017 May 10. Am J Clin Nutr. 2017. PMID: 28490514 Clinical Trial.
Background: Vitamin D supplementation has been proposed as a potential strategy to prevent type 2 diabetes. Existing clinical trials have been limited by short duration, low doses of vitamin D, variability in participants' vitamin D-deficiency status, and the use of surrog …
Background: Vitamin D supplementation has been proposed as a potential strategy to prevent type 2 diabetes. Existing clinical trials …
Serum 25-hydroxyvitamin D concentrations are associated with nuclear factor kappa-B activity but not with inflammatory markers in healthy normoglycemic adults.
Mousa A, de Courten MPJ, Forbes J, de Courten B. Mousa A, et al. J Steroid Biochem Mol Biol. 2018 Mar;177:216-222. doi: 10.1016/j.jsbmb.2017.07.013. Epub 2017 Jul 18. J Steroid Biochem Mol Biol. 2018. PMID: 28732679
Although in-vitro studies suggest that vitamin D inhibits NFκB activity, our novel cross-sectional data from a cohort of healthy individuals suggest that vitamin D may regulate rather than inhibit the NFκB pathway. ...
Although in-vitro studies suggest that vitamin D inhibits NFκB activity, our novel cross-sectional data from a cohort of healthy indi …
Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: Relationships with obesity and insulin resistance.
Naderpoor N, Shorakae S, Abell SK, Mousa A, Joham AE, Moran LJ, Stepto NK, Spritzer PM, Teede HJ, de Courten B. Naderpoor N, et al. Among authors: mousa a. J Steroid Biochem Mol Biol. 2018 Mar;177:209-215. doi: 10.1016/j.jsbmb.2017.07.012. Epub 2017 Jul 19. J Steroid Biochem Mol Biol. 2018. PMID: 28734987
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). ...In a cross sectional study using bio-banked samples, we measured 25(OH)D, DBP and albumin. Bioavailable …
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin re …
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