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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 3
1999 10
2000 5
2001 10
2002 14
2003 9
2004 12
2005 12
2006 13
2007 10
2008 24
2009 27
2010 24
2011 34
2012 32
2013 26
2014 21
2015 39
2016 32
2017 33
2018 43
2019 39
2020 36
2021 40
2022 35
2023 40
2024 11

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563 results

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Page 1
Affinity-coupled CCL22 promotes positive selection in germinal centres.
Liu B, Lin Y, Yan J, Yao J, Liu D, Ma W, Wang J, Liu W, Wang C, Zhang L, Qi H. Liu B, et al. Nature. 2021 Apr;592(7852):133-137. doi: 10.1038/s41586-021-03239-2. Epub 2021 Feb 17. Nature. 2021. PMID: 33597749
Here we show that, upon stimulation of CD40, GC B cells upregulate the chemokine CCL22 and to a lesser extent CCL17. By engaging the chemokine receptor CCR4 on T(FH) cells, CCL22 and CCL17 can attract multiple helper cells from a distance, thus increasing the chance …
Here we show that, upon stimulation of CD40, GC B cells upregulate the chemokine CCL22 and to a lesser extent CCL17. By engaging the …
Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis.
Hou DD, Zhang W, Gao YL, Sun YZ, Wang HX, Qi RQ, Chen HD, Gao XH. Hou DD, et al. Int Immunopharmacol. 2019 Sep;74:105676. doi: 10.1016/j.intimp.2019.105676. Epub 2019 Jun 7. Int Immunopharmacol. 2019. PMID: 31181406
In this study, the anti-inflammatory mechanisms of Quercetin (Que) on atopic dermatitis (AD)-like skin lesions was examined. The left ear of mice was applied with MC903, followed by Que. administration daily on the ear for 8 days. Then macroscopic and histologic examinatio …
In this study, the anti-inflammatory mechanisms of Quercetin (Que) on atopic dermatitis (AD)-like skin lesions was examined. The left ear of …
CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells.
Feng G, Bajpai G, Ma P, Koenig A, Bredemeyer A, Lokshina I, Lai L, Förster I, Leuschner F, Kreisel D, Lavine KJ. Feng G, et al. Circulation. 2022 Mar 8;145(10):765-782. doi: 10.1161/CIRCULATIONAHA.121.055888. Epub 2022 Feb 3. Circulation. 2022. PMID: 35113652 Free PMC article.
We observed increased abundance of regulatory T cells (Tregs) in the myocardium of injured Ccl17 knockout mice. CCL17 inhibited Treg recruitment through biased activation of CCR4. CCL17 activated Gq signaling and CCL22 (C-C chemokine ligand 22) activated both Gq and …
We observed increased abundance of regulatory T cells (Tregs) in the myocardium of injured Ccl17 knockout mice. CCL17 inhibited Treg …
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.
Baer C, Kimura S, Rana MS, Kleist AB, Flerlage T, Feith DJ, Chockley P, Walter W, Meggendorfer M, Olson TL, Cheon H, Olson KC, Ratan A, Mueller ML, Foran JM, Janke LJ, Qu C, Porter SN, Pruett-Miller SM, Kalathur RC, Haferlach C, Kern W, Paietta E, Thomas PG, Babu MM, Loughran TP Jr, Iacobucci I, Haferlach T, Mullighan CG. Baer C, et al. Nat Genet. 2022 May;54(5):637-648. doi: 10.1038/s41588-022-01059-2. Epub 2022 May 5. Nat Genet. 2022. PMID: 35513723 Free PMC article.
In the present study, we report somatic mutations in the chemokine gene CCL22 as the hallmark of a distinct subset of CLPD-NK. CCL22 mutations were enriched at highly conserved residues, mutually exclusive of STAT3 mutations and associated with gene expression progr …
In the present study, we report somatic mutations in the chemokine gene CCL22 as the hallmark of a distinct subset of CLPD-NK. CCL …
CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance.
Montane J, Obach M, Alvarez S, Bischoff L, Dai DL, Soukhatcheva G, Priatel JJ, Hardenberg G, Levings MK, Tan R, Orban PC, Verchere CB. Montane J, et al. Cell Transplant. 2015;24(10):2143-54. doi: 10.3727/096368914X685249. Cell Transplant. 2015. PMID: 26423995 Free article.
Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine CCL22 prevents diabetes in NOD mice and delays recurrent autoimmunity in syngeneic islet transplants. We sought to determine whether attracting Tregs with CCL22 also preve …
Manipulation of regulatory T cell (Treg) migration by islet expression of the chemokine CCL22 prevents diabetes in NOD mice an …
Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.
Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN. Jha AK, et al. Immunity. 2015 Mar 17;42(3):419-30. doi: 10.1016/j.immuni.2015.02.005. Immunity. 2015. PMID: 25786174 Free article.
Correspondingly, glutamine deprivation or inhibition of N-glycosylation decreased M2 polarization and production of chemokine CCL22. In M1 macrophages, we identified a metabolic break at Idh, the enzyme that converts isocitrate to alpha-ketoglutarate, providing mechanistic …
Correspondingly, glutamine deprivation or inhibition of N-glycosylation decreased M2 polarization and production of chemokine CCL22. …
CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes.
Rawat K, Tewari A, Li X, Mara AB, King WT, Gibbings SL, Nnam CF, Kolling FW, Lambrecht BN, Jakubzick CV. Rawat K, et al. J Exp Med. 2023 Jun 5;220(6):e20222129. doi: 10.1084/jem.20222129. Epub 2023 Mar 22. J Exp Med. 2023. PMID: 36946983 Free PMC article.
In steady-state and following inhalation of several PAMPs, scRNA-seq identified LN mononuclear phagocytes as monocytes, resident, or migratory type 1 and type 2 conventional (c)DCs, despite the downregulation of Xcr1, Clec9a, H2-Ab1, Sirpa, and Clec10a transcripts on migratory cD …
In steady-state and following inhalation of several PAMPs, scRNA-seq identified LN mononuclear phagocytes as monocytes, resident, or migrato …
Intratumoral stem-like CCR4+ regulatory T cells orchestrate the immunosuppressive microenvironment in HCC associated with hepatitis B.
Gao Y, You M, Fu J, Tian M, Zhong X, Du C, Hong Z, Zhu Z, Liu J, Markowitz GJ, Wang FS, Yang P. Gao Y, et al. J Hepatol. 2022 Jan;76(1):148-159. doi: 10.1016/j.jhep.2021.08.029. Epub 2021 Sep 12. J Hepatol. 2022. PMID: 34689996
To block CCR4(+) Treg chemotaxis, we developed an N-terminus recombinant protein of CCR4 (N-CCR4-Fc) as a neutralizing pseudo-receptor that effectively bound to its ligand CCL22. The efficacy of CCR4 antagonism as an immunotherapeutic agent was evaluated by tumor weights, …
To block CCR4(+) Treg chemotaxis, we developed an N-terminus recombinant protein of CCR4 (N-CCR4-Fc) as a neutralizing pseudo-receptor that …
CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment.
Lecoq I, Kopp KL, Chapellier M, Mantas P, Martinenaite E, Perez-Penco M, Rønn Olsen L, Zocca MB, Wakatsuki Pedersen A, Andersen MH. Lecoq I, et al. Oncoimmunology. 2022 Aug 29;11(1):2115655. doi: 10.1080/2162402X.2022.2115655. eCollection 2022. Oncoimmunology. 2022. PMID: 36052217 Free PMC article.
The present study aimed to provide a rationale for developing a CCL22-targeting immunotherapy. Vaccination with CCL22-derived peptides induced CCL22-specific T-cell responses in both BALB/c and C57BL/6 mice, assessed by interferon-gamma secretion ex vi …
The present study aimed to provide a rationale for developing a CCL22-targeting immunotherapy. Vaccination with CCL22-derived …
Melanoma exosomes promote mixed M1 and M2 macrophage polarization.
Bardi GT, Smith MA, Hood JL. Bardi GT, et al. Cytokine. 2018 May;105:63-72. doi: 10.1016/j.cyto.2018.02.002. Epub 2018 Feb 17. Cytokine. 2018. PMID: 29459345 Free PMC article.
Upregulation of markers common to both M1 and M2 polarization phenotypes included CCL22, IL-12B, IL-1beta, IL-6, i-NOS, and TNF-alpha. The M2 cytokine TGF-beta was upregulated in primary but not RAW 264.7 macrophages. ...
Upregulation of markers common to both M1 and M2 polarization phenotypes included CCL22, IL-12B, IL-1beta, IL-6, i-NOS, and TNF-alpha …
563 results