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Page 1
DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.
Wang Q, Cao W, Yang ZG, Zhao GF. Wang Q, et al. Int J Clin Exp Med. 2015 Oct 15;8(10):17565-77. eCollection 2015. Int J Clin Exp Med. 2015. PMID: 26770347 Free PMC article.
BACKGROUND: Anti-CD11c antibodies target to the CD11c receptor that mediates antigen presentation to T cells by dendritic cells (DCs). To exploit these properties for immunization purposes, we obtained DC-targeting DNA vaccines by fusing tumor-associated a
BACKGROUND: Anti-CD11c antibodies target to the CD11c receptor that mediates antigen presentation to T cells by dendrit …
CD11c/CD18: novel ligands and a role in delayed-type hypersensitivity.
Sadhu C, Ting HJ, Lipsky B, Hensley K, Garcia-Martinez LF, Simon SI, Staunton DE. Sadhu C, et al. J Leukoc Biol. 2007 Jun;81(6):1395-403. doi: 10.1189/jlb.1106680. Epub 2007 Mar 27. J Leukoc Biol. 2007. PMID: 17389580
We discovered that the anti-mouse CD11c mAb N418 blocks CD11c binding to iC3b, ICAM-1, and VCAM-1. Treatment of mice with N418 reduced SRBC-induced delayed-type hypersensitivity significantly. ...
We discovered that the anti-mouse CD11c mAb N418 blocks CD11c binding to iC3b, ICAM-1, and VCAM-1. Treatment of …
Rapid monoclonal antibody generation via dendritic cell targeting in vivo.
Berry JD, Licea A, Popkov M, Cortez X, Fuller R, Elia M, Kerwin L, Kubitz D, Barbas CF 3rd. Berry JD, et al. Hybrid Hybridomics. 2003 Feb;22(1):23-31. doi: 10.1089/153685903321538053. Hybrid Hybridomics. 2003. PMID: 12713687
However, the utility of this strategy for the generation of MAbs has not been investigated. To address this question we immunized mice with IgG-peptide conjugates prepared with the hamster anti-murine CD11c MAb N418. ...Spleen cells from N418-peptide i …
However, the utility of this strategy for the generation of MAbs has not been investigated. To address this question we immunized mice
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.
Metlay JP, Witmer-Pack MD, Agger R, Crowley MT, Lawless D, Steinman RM. Metlay JP, et al. J Exp Med. 1990 May 1;171(5):1753-71. doi: 10.1084/jem.171.5.1753. J Exp Med. 1990. PMID: 2185332 Free PMC article.
The second mAb, N418, precipitated a 150, 90 kD heterodimer that shared the 2E6 CD18 epitope. This N418 epitope may be the murine homologue of the previously characterized human CD11c molecule, but the epitope was only detected on dendritic cells. ...
The second mAb, N418, precipitated a 150, 90 kD heterodimer that shared the 2E6 CD18 epitope. This N418 epitope may be the mur …
Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli.
Kou G, Shi S, Wang H, Tan M, Xue J, Zhang D, Hou S, Qian W, Wang S, Dai J, Li B, Guo Y. Kou G, et al. Protein Expr Purif. 2007 Mar;52(1):131-8. doi: 10.1016/j.pep.2006.08.007. Epub 2006 Aug 23. Protein Expr Purif. 2007. PMID: 17027283
The 3'-terminal end of the ScFv was ligated to the gene for MHC class I molecule-recognized peptide from mouse tyrosine-related protein 2 (TRP2). Using this vector, we have expressed and purified ScFv(CD11c)-TRP2, a fusion protein that could target TRP2 peptide to …
The 3'-terminal end of the ScFv was ligated to the gene for MHC class I molecule-recognized peptide from mouse tyrosine-related prote …
Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization.
Wang H, Griffiths MN, Burton DR, Ghazal P. Wang H, et al. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):847-52. doi: 10.1073/pnas.97.2.847. Proc Natl Acad Sci U S A. 2000. PMID: 10639168 Free PMC article.
We have compared the kinetics of antibody responses in conventional and dendritic cell-targeted immunization by using a model antigen in mice. Targeting was achieved by linking the reporter antigen (polyclonal goat anti-hamster antibody) to N418, a ham …
We have compared the kinetics of antibody responses in conventional and dendritic cell-targeted immunization by using a model antigen
Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion.
Finkelman FD, Lees A, Birnbaum R, Gause WC, Morris SC. Finkelman FD, et al. J Immunol. 1996 Aug 15;157(4):1406-14. J Immunol. 1996. PMID: 8759720
Injection of mice with 1 ng/100 micrograms of 33D1 rarely induced an anti-rat IgG2b Ab response and, in most mice, induced rat IgG2b-specific T cell and B cell tolerance. ...Not all anti-DC mAbs are tolerogenic. Injection of a DC-specific hamster anti-CD11c m …
Injection of mice with 1 ng/100 micrograms of 33D1 rarely induced an anti-rat IgG2b Ab response and, in most mice, induced rat …
Specific stabilization of the 4F7 molecule on dendritic cells by contact allergens.
Jonuleit H, Lohmann S, Müller G, Lempertz U, Enk A, Knop J. Jonuleit H, et al. Arch Dermatol Res. 1996 Nov;288(12):745-52. doi: 10.1007/BF02505291. Arch Dermatol Res. 1996. PMID: 8950454
Our laboratory has recently developed the monoclonal antibody 4F7 which recognizes a molecule on dendritic cells in the dermis of mice that is upregulated after application of contact allergens in vivo. ...Freshly isolated splenic dendritic cells were found to be positive …
Our laboratory has recently developed the monoclonal antibody 4F7 which recognizes a molecule on dendritic cells in the dermis of mice
CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth.
Esche C, Gambotto A, Satoh Y, Gerein V, Robbins PD, Watkins SC, Lotze MT, Shurin MR. Esche C, et al. Eur J Immunol. 1999 Jul;29(7):2148-55. doi: 10.1002/(SICI)1521-4141(199907)29:07<2148::AID-IMMU2148>3.0.CO;2-F. Eur J Immunol. 1999. PMID: 10427977 Free article.
Retroviral transduction of MC38 colon carcinoma cells with the CD154 gene resulted in inhibition of tumor growth. This effect was abrogated in IL-12 knockout mice. Immunohistochemical analysis revealed an increase in CD11c+ (N418) and CD8+ but not NLDC-145+ c …
Retroviral transduction of MC38 colon carcinoma cells with the CD154 gene resulted in inhibition of tumor growth. This effect was abrogated …
Single chain antibody fragments for the selective targeting of antigens to dendritic cells.
Demangel C, Zhou J, Choo AB, Shoebridge G, Halliday GM, Britton WJ. Demangel C, et al. Mol Immunol. 2005 May;42(8):979-85. doi: 10.1016/j.molimm.2004.09.034. Epub 2004 Dec 10. Mol Immunol. 2005. PMID: 15829289
In order to target antigens (Ags) selectively to dendritic cells (DC), we derived single chain antibody fragments (scFvs) from NLDC-145 and N418, two monoclonal antibodies binding the mouse dendritic cell-restricted surface molecules DEC-205 and CD11c. ...Imm …
In order to target antigens (Ags) selectively to dendritic cells (DC), we derived single chain antibody fragments (scFvs) from NLDC-145 and …
11 results