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Self-renewal of B-1 lymphocytes is dependent on CD19.
Krop I, de Fougerolles AR, Hardy RR, Allison M, Schlissel MS, Fearon DT. Krop I, et al. Eur J Immunol. 1996 Jan;26(1):238-42. doi: 10.1002/eji.1830260137. Eur J Immunol. 1996. PMID: 8566073
Pre-natal treatment of mice with 1D3, a rat anti-mouse CD19 monoclonal antibody, down-regulated CD19 expression and reduced by sixfold the number of B-1a cells at birth; B-2 cells were relatively unaffected. Prolonged treatment of adult mice
Pre-natal treatment of mice with 1D3, a rat anti-mouse CD19 monoclonal antibody, down-regulated CD19 expr …
Selective B cell depletion upon intravenous infusion of replication-incompetent anti-CD19 CAR lentivirus.
Rive CM, Yung E, Dreolini L, Brown SD, May CG, Woodsworth DJ, Holt RA. Rive CM, et al. Mol Ther Methods Clin Dev. 2022 May 29;26:4-14. doi: 10.1016/j.omtm.2022.05.006. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 35755944 Free PMC article.
To explore this approach we administered approximately 20 million replication-incompetent vesicular stomatitis virus G protein (VSV-G) lentiviral particles carrying an anti-CD19CAR-2A-GFP transgene comprising either an FMC63 (human) or 1D3 (murine) anti-CD19 binding …
To explore this approach we administered approximately 20 million replication-incompetent vesicular stomatitis virus G protein (VSV-G) lenti …