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112 results

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Page 1
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytes.
Setiady YY, Coccia JA, Park PU. Setiady YY, et al. Eur J Immunol. 2010 Mar;40(3):780-6. doi: 10.1002/eji.200939613. Eur J Immunol. 2010. PMID: 20039297 Free article.
Depletion of CD4(+)CD25(+)FoxP3(+) Treg using PC61 mAb (anti-murine CD25 rat IgG1) is widely used to characterize Treg function in vivo. However, the mechanism of Treg depletion remains largely unknown. Herein, we report the PC61 mAb's mechanism of act …
Depletion of CD4(+)CD25(+)FoxP3(+) Treg using PC61 mAb (anti-murine CD25 rat IgG1) is widely used to characterize Treg …
Partial depletion of CD69low-expressing natural regulatory T cells with the anti-CD25 monoclonal antibody PC61.
McNeill A, Spittle E, Bäckström BT. McNeill A, et al. Scand J Immunol. 2007 Jan;65(1):63-9. doi: 10.1111/j.1365-3083.2006.01870.x. Scand J Immunol. 2007. PMID: 17212768 Free article.
Much of the work to date has used the activation marker CD25 to define, enrich and deplete Treg. However, the identification of FoxP3 as a definitive marker of Treg has allowed us to study the effect of monoclonal antibodies against CD25 on regulatory T-cell populat …
Much of the work to date has used the activation marker CD25 to define, enrich and deplete Treg. However, the identification of FoxP3 …
PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection.
Kraft AR, Wlodarczyk MF, Kenney LL, Selin LK. Kraft AR, et al. J Virol. 2013 Dec;87(23):12636-47. doi: 10.1128/JVI.00936-13. Epub 2013 Sep 18. J Virol. 2013. PMID: 24049180 Free PMC article.
Treg cell and interleukin-10 (IL-10) levels remained elevated in the lungs and mediastinal lymph nodes (mLNs) throughout the acute LCMV response of IAV-immune mice. PC61 treatment, used to decrease Treg cell levels, did not change LCMV titers but resulted in a surpr …
Treg cell and interleukin-10 (IL-10) levels remained elevated in the lungs and mediastinal lymph nodes (mLNs) throughout the acute LCMV resp …
LdIL-2 treatment in ASD: a novel immunotherapeutic approach targeting Th/Treg dysfunction and neuroinflammation.
Li M, Kui X, Yang S, Nie Z, Chen H, Yao P, Xu X, Shen C, Li Z, Zhao H, Wen J, Huang X, Yang J, Yan J, Wang P, Li B, Cao X. Li M, et al. Transl Psychiatry. 2025 Oct 6;15(1):376. doi: 10.1038/s41398-025-03609-8. Transl Psychiatry. 2025. PMID: 41053009 Free PMC article.
Neuroinflammatory proteins in cerebrospinal fluid were assessed using proteomic analysis. Furthermore, CD25(+) Treg cells were depleted using PC61, followed by LdIL-2 intervention, to determine the role of Treg cells in LdIL-2-treated BTBR mice. ...Central ne …
Neuroinflammatory proteins in cerebrospinal fluid were assessed using proteomic analysis. Furthermore, CD25(+) Treg cells were deplet …
A CD25-CCR7 complex initiates non-canonical IL-2 signaling.
Kim SHJ, Lee H, Gingras A, Ley K, Spangler JB, Ginsberg MH. Kim SHJ, et al. bioRxiv [Preprint]. 2025 Feb 4:2025.02.03.636356. doi: 10.1101/2025.02.03.636356. bioRxiv. 2025. Update in: J Biol Chem. 2026 Jan;302(1):110981. doi: 10.1016/j.jbc.2025.110981. PMID: 39975281 Free PMC article. Updated. Preprint.
An anti-mouse CD25 antibody, PC61, triggers alternative IL-2 signaling, leading to integrin activation. PC61 induces a complex formed by the IL-2-dependent association of CD25 with CCR7, suggesting that the formation of this complex initiates al …
An anti-mouse CD25 antibody, PC61, triggers alternative IL-2 signaling, leading to integrin activation. PC61 ind …
Reduction of Foxp3+ cells by depletion with the PC61 mAb induces mortality in resistant BALB/c mice infected with Toxoplasma gondii.
Tenorio EP, Olguín JE, Fernández J, Vieyra P, Saavedra R. Tenorio EP, et al. J Biomed Biotechnol. 2010;2010:786078. doi: 10.1155/2010/786078. Epub 2009 Dec 13. J Biomed Biotechnol. 2010. PMID: 20037737 Free PMC article.
The aim of this work is to study the role of Tregs during the infection with the intracellular protozoan Toxoplasma gondii. Resistant BALB/c mice were injected with 200 microg of anti-CD25 mAb (clone PC61) and 2 days later they were infected with 20 cysts of …
The aim of this work is to study the role of Tregs during the infection with the intracellular protozoan Toxoplasma gondii. Resistant BALB/c …
Inflammatory arthritis and dermatitis in thymectomized, CD25+ cell-depleted adult mice.
Loughry A, Fairchild S, Athanasou N, Edwards J, Hall FC. Loughry A, et al. Rheumatology (Oxford). 2005 Mar;44(3):299-308. doi: 10.1093/rheumatology/keh477. Epub 2005 Jan 5. Rheumatology (Oxford). 2005. PMID: 15637034
RESULTS: In the thymectomized mice treated with PC61, the CD25+ population was depleted and a spontaneous arthritis developed (P = 0.03). ...However, no significant difference in the natural history of arthritis was evident in mice treated with CD25 …
RESULTS: In the thymectomized mice treated with PC61, the CD25+ population was depleted and a spontaneous arthritis dev …
Depletion with PC61 mAb before Toxoplasma gondii infection eliminates mainly Tregs in BALB/c mice, but activated cells in C57BL/6J mice.
Tenorio EP, Fernández J, Olguín JE, Saavedra R. Tenorio EP, et al. FEMS Immunol Med Microbiol. 2011 Aug;62(3):362-7. doi: 10.1111/j.1574-695X.2011.00805.x. Epub 2011 May 6. FEMS Immunol Med Microbiol. 2011. PMID: 21477004 Free article.
We show in this paper that treatment with anti-CD25 mAb before Toxoplasma gondii infection eliminates a different pattern of cell subsets in the resistant BALB/c and the susceptible C57BL/6J mouse strain. Injection with PC61 mAb leads to the elimination of mo …
We show in this paper that treatment with anti-CD25 mAb before Toxoplasma gondii infection eliminates a different pattern of cell sub …
Protective effect of CD4(+)CD25(high)CD127(low) regulatory T cells in renal ischemia-reperfusion injury.
Jun C, Ke W, Qingshu L, Ping L, Jun D, Jie L, Bo C, Su M. Jun C, et al. Cell Immunol. 2014 May-Jun;289(1-2):106-11. doi: 10.1016/j.cellimm.2014.04.002. Epub 2014 Apr 12. Cell Immunol. 2014. PMID: 24754976
Regulatory T cells (Tregs) suppress excessive immune responses in IRI. We investigated the role of CD4(+)CD25(high)CD127(low) Tregs in the early phase of renal IRI pathogenesis in a mouse model. ...PC61, an anti-CD25 monoclonal antibody, was used to de …
Regulatory T cells (Tregs) suppress excessive immune responses in IRI. We investigated the role of CD4(+)CD25(high)CD127(low) Tregs i …
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Onizuka S, et al. Cancer Res. 1999 Jul 1;59(13):3128-33. Cancer Res. 1999. PMID: 10397255
In this study, we demonstrated that a single in vivo administration of an amount less than 0.125 mg of anti-CD25 interleukin 2 receptor alpha monoclonal antibody (mAb; PC61) caused the regression of tumors that grew progressively in syngeneic mice. The tumors …
In this study, we demonstrated that a single in vivo administration of an amount less than 0.125 mg of anti-CD25 interleukin 2 recept …
112 results