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1,105 results

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Page 1
An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment.
Fu Y, Wang J, Zhou B, Pajulas A, Gao H, Ramdas B, Koh B, Ulrich BJ, Yang S, Kapur R, Renauld JC, Paczesny S, Liu Y, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Tepper RS, Sun J, Kaplan MH. Fu Y, et al. Sci Immunol. 2022 Feb 18;7(68):eabi9768. doi: 10.1126/sciimmunol.abi9768. Epub 2022 Feb 18. Sci Immunol. 2022. PMID: 35179949 Free PMC article.
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9-responsive cell repertoire is still not well defined. ...Interstitial macrophages were required for IL-9-dependent allergic responses. Mechanistically, …
Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9-responsive cell repertoire …
Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9.
Fu Y, Pajulas A, Wang J, Zhou B, Cannon A, Cheung CCL, Zhang J, Zhou H, Fisher AJ, Omstead DT, Khan S, Han L, Renauld JC, Paczesny S, Gao H, Liu Y, Yang L, Tighe RM, Licona-Limón P, Flavell RA, Takatsuka S, Kitamura D, Sun J, Bilgicer B, Sears CR, Yang K, Kaplan MH. Fu Y, et al. Nat Commun. 2022 Jul 1;13(1):3811. doi: 10.1038/s41467-022-31596-7. Nat Commun. 2022. PMID: 35778404 Free PMC article.
Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, and is required for lung tumor growth in multiple mouse models. ...Moreover, targeting IL-9 signaling using macrophage-specific nan …
Here, we show that IL-9 signaling is associated with poor outcomes in patients with various forms of lung cancer, and is requi …
IL-9/STAT3/fatty acid oxidation-mediated lipid peroxidation contributes to Tc9 cell longevity and enhanced antitumor activity.
Xiao L, Ma X, Ye L, Su P, Xiong W, Bi E, Wang Q, Xian M, Yang M, Qian J, Yi Q. Xiao L, et al. J Clin Invest. 2022 Apr 1;132(7):e153247. doi: 10.1172/JCI153247. J Clin Invest. 2022. PMID: 35192544 Free PMC article.
Although in vitro-polarized, transferred IL-9-secreting CD8+ Tc9 (cytotoxic T lymphocyte subset 9) cells exert greater persistence and antitumor efficacy than Tc1 cells, the underlying mechanism remains unclear. ...IL-9 signaling deficiency, inhibiting …
Although in vitro-polarized, transferred IL-9-secreting CD8+ Tc9 (cytotoxic T lymphocyte subset 9) cells exert greater persist …
IL-9 by INFERence.
Zhou B, Kaplan MH. Zhou B, et al. Immunity. 2013 Oct 17;39(4):627-9. doi: 10.1016/j.immuni.2013.09.010. Immunity. 2013. PMID: 24138877 Free PMC article.
Despite the discovery of the cytokine over 20 years ago, the relevant biological sources of interleukin-9 (IL-9) have remained a mystery. In this issue of Immunity, Licona-Limon et al. (2013) use a newly generated reporter mouse to demonstrate a …
Despite the discovery of the cytokine over 20 years ago, the relevant biological sources of interleukin-9 (IL-9) …
IL-9 stimulates an anti-tumor immune response and facilitates immune checkpoint blockade in the CMT167 mouse model.
Feng Y, Yan S, Lam SK, Ko FCF, Chen C, Khan M, Ho JC. Feng Y, et al. Lung Cancer. 2022 Dec;174:14-26. doi: 10.1016/j.lungcan.2022.10.002. Epub 2022 Oct 12. Lung Cancer. 2022. PMID: 36272280 Free article.
OBJECTIVES: There is mounting evidence that interleukin-9 (IL-9) is associated with various cancers although its function in lung cancer remains elusive. ...In CMT167 tumors, while IL-9 increased CD4(+) and CD8(+) T cells and dendritic ce …
OBJECTIVES: There is mounting evidence that interleukin-9 (IL-9) is associated with various cancers although its …
IL-9 contributes to the host immune response against Helicobacter pylori and helps limit infection in a Mouse Model.
He Y, Ning J, Li B, Guo H, Hao N, Wu C. He Y, et al. Helicobacter. 2021 Oct;26(5):e12827. doi: 10.1111/hel.12827. Epub 2021 Jul 7. Helicobacter. 2021. PMID: 34231938
BACKGROUND: As an important mediator in lots of diseases, interleukin-9 (IL-9) can be a protector or pro-inflammatory cytokine depending on the complicated inflammatory milieu. Helicobacter pylori (H. pylori) induced a series of immunology cells and cy …
BACKGROUND: As an important mediator in lots of diseases, interleukin-9 (IL-9) can be a protector or pro-inflamm …
Inhibitory effect of activin A on IL-9 production by mouse NK cells through Smad3 signaling.
Ma C, Qi Y, Liu H, Wu C, Cui X, Liu Z. Ma C, et al. Biol Chem. 2020 Feb 25;401(2):297-308. doi: 10.1515/hsz-2019-0245. Biol Chem. 2020. PMID: 31400749
Interleukin-9 (IL-9) is a cytokine secreted by T-helper (Th)9 cells, and activin A can enhance Th9 cell differentiation. ...Although activin A promoted IL-9 expression in CD4+ Th cells, it inhibited IL-9 production by CD49b+ …
Interleukin-9 (IL-9) is a cytokine secreted by T-helper (Th)9 cells, and activin A can enhance Th9 cell differen …
DUSP8 induces TGF-beta-stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-alpha.
Chuang HC, Hsueh CH, Hsu PM, Tsai CY, Shih YC, Chiu HY, Chen YM, Yu WK, Chen MH, Tan TH. Chuang HC, et al. J Clin Invest. 2023 Nov 1;133(21):e166269. doi: 10.1172/JCI166269. J Clin Invest. 2023. PMID: 37909329 Free PMC article.
Using T cell-specific Dusp8 conditional KO (T-Dusp8 cKO) mice, mass spectrometry analysis, ChIP-Seq, and immune analysis, we found that DUSP8 interacted with Pur-alpha, stimulated interleukin-9 (IL-9) gene expression, and promoted Th9 differenti …
Using T cell-specific Dusp8 conditional KO (T-Dusp8 cKO) mice, mass spectrometry analysis, ChIP-Seq, and immune analysis, we found th …
The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D. Klose CSN, et al. Nature. 2017 Sep 14;549(7671):282-286. doi: 10.1038/nature23676. Epub 2017 Sep 6. Nature. 2017. PMID: 28869965 Free PMC article.
The type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have important roles in stimulating innate and adaptive immune responses that are required for resistance to helminth infection, promotion of allergic inflammation, metabolic homeostasis and tissue repair …
The type 2 cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13 have important roles in stimulating innate and adaptive immune r …
Targeting the IL-9 pathway in cancer immunotherapy.
Zheng N, Lu Y. Zheng N, et al. Hum Vaccin Immunother. 2020 Oct 2;16(10):2333-2340. doi: 10.1080/21645515.2019.1710413. Epub 2020 Feb 10. Hum Vaccin Immunother. 2020. PMID: 32040369 Free PMC article. Review.
The role of IL-9 was originally known in allergic disease and parasite infections. Interestingly, recent studies demonstrate its presence in the tumor tissues of mice and humans, and the association between IL-9 and tumor progression has been re …
The role of IL-9 was originally known in allergic disease and parasite infections. Interestingly, recent studies demonstrate i …
1,105 results