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71 results
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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
Schnur RC, Corman ML, Gallaschun RJ, Cooper BA, Dee MF, Doty JL, Muzzi ML, Moyer JD, DiOrio CI, Barbacci EG, et al. Schnur RC, et al. Among authors: moyer jd. J Med Chem. 1995 Sep 15;38(19):3806-12. doi: 10.1021/jm00019a010. J Med Chem. 1995. PMID: 7562911
Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents.
Jun M, Bacay AF, Moyer J, Webb A, Carrico-Moniz D. Jun M, et al. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4654-4658. doi: 10.1016/j.bmcl.2014.08.038. Epub 2014 Aug 26. Bioorg Med Chem Lett. 2014. PMID: 25205194
The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer.
Lippa B, Kauffman GS, Arcari J, Kwan T, Chen J, Hungerford W, Bhattacharya S, Zhao X, Williams C, Xiao J, Pustilnik L, Su C, Moyer JD, Ma L, Campbell M, Steyn S. Lippa B, et al. Among authors: moyer jd. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3081-6. doi: 10.1016/j.bmcl.2007.03.046. Epub 2007 Mar 19. Bioorg Med Chem Lett. 2007. PMID: 17398092
Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.
Jani JP, Finn RS, Campbell M, Coleman KG, Connell RD, Currier N, Emerson EO, Floyd E, Harriman S, Kath JC, Morris J, Moyer JD, Pustilnik LR, Rafidi K, Ralston S, Rossi AM, Steyn SJ, Wagner L, Winter SM, Bhattacharya SK. Jani JP, et al. Among authors: moyer jd. Cancer Res. 2007 Oct 15;67(20):9887-93. doi: 10.1158/0008-5472.CAN-06-3559. Cancer Res. 2007. PMID: 17942920
PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.
Jani JP, Arcari J, Bernardo V, Bhattacharya SK, Briere D, Cohen BD, Coleman K, Christensen JG, Emerson EO, Jakowski A, Hook K, Los G, Moyer JD, Pruimboom-Brees I, Pustilnik L, Rossi AM, Steyn SJ, Su C, Tsaparikos K, Wishka D, Yoon K, Jakubczak JL. Jani JP, et al. Among authors: moyer jd. Mol Cancer Ther. 2010 Apr;9(4):883-94. doi: 10.1158/1535-7163.MCT-09-0915. Epub 2010 Mar 30. Mol Cancer Ther. 2010. PMID: 20354118
Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871.
Cohen BD, Baker DA, Soderstrom C, Tkalcevic G, Rossi AM, Miller PE, Tengowski MW, Wang F, Gualberto A, Beebe JS, Moyer JD. Cohen BD, et al. Among authors: moyer jd. Clin Cancer Res. 2005 Mar 1;11(5):2063-73. doi: 10.1158/1078-0432.CCR-04-1070. Clin Cancer Res. 2005. PMID: 15756033
Achieving selectivity between highly homologous tyrosine kinases: a novel selective erbB2 inhibitor.
Bhattacharya SK, Cox ED, Kath JC, Mathiowetz AM, Morris J, Moyer JD, Pustilnik LR, Rafidi K, Richter DT, Su C, Wessel MD. Bhattacharya SK, et al. Among authors: moyer jd. Biochem Biophys Res Commun. 2003 Jul 25;307(2):267-73. doi: 10.1016/s0006-291x(03)01160-4. Biochem Biophys Res Commun. 2003. PMID: 12859950
The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells.
Barbacci EG, Pustilnik LR, Rossi AM, Emerson E, Miller PE, Boscoe BP, Cox ED, Iwata KK, Jani JP, Provoncha K, Kath JC, Liu Z, Moyer JD. Barbacci EG, et al. Among authors: moyer jd. Cancer Res. 2003 Aug 1;63(15):4450-9. Cancer Res. 2003. PMID: 12907618
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice.
Pollack VA, Savage DM, Baker DA, Tsaparikos KE, Sloan DE, Moyer JD, Barbacci EG, Pustilnik LR, Smolarek TA, Davis JA, Vaidya MP, Arnold LD, Doty JL, Iwata KK, Morin MJ. Pollack VA, et al. Among authors: moyer jd. J Pharmacol Exp Ther. 1999 Nov;291(2):739-48. J Pharmacol Exp Ther. 1999. PMID: 10525095
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.
Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham A, DiOrio C, Doty J, Morin MJ, Moyer MP, Neveu M, Pollack VA, Pustilnik LR, Reynolds MM, Sloan D, Theleman A, Miller P. Moyer JD, et al. Among authors: moyer mp. Cancer Res. 1997 Nov 1;57(21):4838-48. Cancer Res. 1997. PMID: 9354447
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