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Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.
Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA. Doyle SL, et al. J Biol Chem. 2013 Aug 30;288(35):25066-75. doi: 10.1074/jbc.M113.469122. Epub 2013 Jul 19. J Biol Chem. 2013. PMID: 23873932 Free PMC article.
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity.
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, Taylor CT. Cummins EP, et al. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18154-9. doi: 10.1073/pnas.0602235103. Epub 2006 Nov 17. Proc Natl Acad Sci U S A. 2006. PMID: 17114296 Free PMC article.
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Miggin SM, Pålsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA. Miggin SM, et al. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3372-7. doi: 10.1073/pnas.0608100104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360653 Free PMC article.
The NF-kappaB pathway.
Moynagh PN. Moynagh PN. J Cell Sci. 2005 Oct 15;118(Pt 20):4589-92. doi: 10.1242/jcs.02579. J Cell Sci. 2005. PMID: 16219681 Review. No abstract available.
The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.
Curran NM, Griffin BD, O'Toole D, Brady KJ, Fitzgerald SN, Moynagh PN. Curran NM, et al. J Biol Chem. 2005 Oct 28;280(43):35797-806. doi: 10.1074/jbc.M507959200. Epub 2005 Aug 16. J Biol Chem. 2005. PMID: 16105834
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