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2007 1
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2023 0
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Page 1
Crystal structure of an ancient protein: evolution by conformational epistasis.
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Ortlund EA, et al. Among authors: thornton jw. Science. 2007 Sep 14;317(5844):1544-8. doi: 10.1126/science.1142819. Epub 2007 Aug 16. Science. 2007. PMID: 17702911 Free PMC article.
We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucocorticoid (GR) and mineralocorticoid (MR) receptors. Using structural, phylogenetic, and functional analysis, we identify the specific …
We report x-ray crystal structures of a resurrected ancestral protein-the approximately 450 million-year-old precursor of vertebrate glucoco …
Mechanisms for the evolution of a derived function in the ancestral glucocorticoid receptor.
Carroll SM, Ortlund EA, Thornton JW. Carroll SM, et al. Among authors: thornton jw. PLoS Genet. 2011 Jun;7(6):e1002117. doi: 10.1371/journal.pgen.1002117. Epub 2011 Jun 16. PLoS Genet. 2011. PMID: 21698144 Free PMC article.
Prior work showed that GR and its paralog, the mineralocorticoid receptor (MR), duplicated from a common ancestor roughly 450 million years ago; the ancestral functions were largely conserved in the MR lineage, but the functions of GRs-reduced sensitivity to all hor …
Prior work showed that GR and its paralog, the mineralocorticoid receptor (MR), duplicated from a common ancestor roughly 450 million …
Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.
Carroll SM, Bridgham JT, Thornton JW. Carroll SM, et al. Among authors: thornton jw. Mol Biol Evol. 2008 Dec;25(12):2643-52. doi: 10.1093/molbev/msn204. Epub 2008 Sep 17. Mol Biol Evol. 2008. PMID: 18799714 Free PMC article.
We show that 1alpha-B modulates gene expression in vitro by activating two paralogous intracellular transcription factors, the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), in the little skate Leucoraja erinacea; MR serves as a high-sensitivity a …
We show that 1alpha-B modulates gene expression in vitro by activating two paralogous intracellular transcription factors, the mineralocorti …