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103 results
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A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.
Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR. Zolotarevsky Y, et al. Gastroenterology. 2002 Jul;123(1):163-72. doi: 10.1053/gast.2002.34235. Gastroenterology. 2002. PMID: 12105845
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR. Clayburgh DR, et al. J Clin Invest. 2005 Oct;115(10):2702-15. doi: 10.1172/JCI24970. Epub 2005 Sep 22. J Clin Invest. 2005. PMID: 16184195 Free PMC article.
Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane.
Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, Parkos CA, Nusrat A. Utech M, et al. Mol Biol Cell. 2005 Oct;16(10):5040-52. doi: 10.1091/mbc.e05-03-0193. Epub 2005 Jul 29. Mol Biol Cell. 2005. PMID: 16055505 Free PMC article.
5'-adenosine monophosphate is the neutrophil-derived paracrine factor that elicits chloride secretion from T84 intestinal epithelial cell monolayers.
Madara JL, Patapoff TW, Gillece-Castro B, Colgan SP, Parkos CA, Delp C, Mrsny RJ. Madara JL, et al. J Clin Invest. 1993 May;91(5):2320-5. doi: 10.1172/JCI116462. J Clin Invest. 1993. PMID: 8486793 Free PMC article.
Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.
Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue D, Mrsny RJ, Brayden DJ. Feighery LM, et al. Pharm Res. 2008 Jun;25(6):1377-86. doi: 10.1007/s11095-007-9527-6. Pharm Res. 2008. PMID: 18163202
Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.
Taverner A, Dondi R, Almansour K, Laurent F, Owens SE, Eggleston IM, Fotaki N, Mrsny RJ. Taverner A, et al. J Control Release. 2015 Jul 28;210:189-97. doi: 10.1016/j.jconrel.2015.05.270. Epub 2015 May 14. J Control Release. 2015. PMID: 25980620 Free PMC article.
Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia.
Almansour K, Taverner A, Eggleston IM, Mrsny RJ. Almansour K, et al. Among authors: mrsny rj. J Control Release. 2018 Jun 10;279:208-219. doi: 10.1016/j.jconrel.2018.03.033. Epub 2018 Mar 31. J Control Release. 2018. PMID: 29614254
Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation.
Liang TW, DeMarco RA, Mrsny RJ, Gurney A, Gray A, Hooley J, Aaron HL, Huang A, Klassen T, Tumas DB, Fong S. Liang TW, et al. Am J Physiol Cell Physiol. 2000 Dec;279(6):C1733-43. doi: 10.1152/ajpcell.2000.279.6.C1733. Am J Physiol Cell Physiol. 2000. PMID: 11078687
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