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Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ. Ill-Raga G, et al. Among authors: munoz fj. PLoS One. 2011;6(6):e21456. doi: 10.1371/journal.pone.0021456. Epub 2011 Jun 28. PLoS One. 2011. PMID: 21738672 Free PMC article.
Amyloid-β peptide fibrils induce nitro-oxidative stress in neuronal cells.
Ill-Raga G, Ramos-Fernández E, Guix FX, Tajes M, Bosch-Morató M, Palomer E, Godoy J, Belmar S, Cerpa W, Simpkins JW, Inestrosa And NC, Muñoz FJ. Ill-Raga G, et al. Among authors: munoz fj. J Alzheimers Dis. 2010;22(2):641-52. doi: 10.3233/JAD-2010-100474. J Alzheimers Dis. 2010. PMID: 20858976
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. Among authors: munoz fj. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.
216 results