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Nicotine stereoisomers and cotinine stimulate prostaglandin E2 but inhibit thromboxane B2 and leukotriene E4 synthesis in whole blood.
Saareks V, Mucha I, Sievi E, Vapaatalo H, Riutta A. Saareks V, et al. Among authors: mucha i. Eur J Pharmacol. 1998 Jul 17;353(1):87-92. doi: 10.1016/s0014-2999(98)00384-7. Eur J Pharmacol. 1998. PMID: 9721044
. (-)-Nicotine and (-)-cotinine stimulated prostaglandin E2 but inhibited thromboxane B2 synthesis, as has been observed previously in A23187-stimulated polymorphonuclear leukocytes and platelet-rich plasma [Saareks, V., Riutta, A., Mucha, I., Alanko, J., Vapaatalo, …
. (-)-Nicotine and (-)-cotinine stimulated prostaglandin E2 but inhibited thromboxane B2 synthesis, as has been observed previously in A2318 …
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