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Genetic Deficiency of Complement Component 3 Does Not Alter Disease Progression in a Mouse Model of Huntington's Disease.

Larkin PB, Muchowski PJ. Larkin PB, et al. Among authors: muchowski pj. J Huntingtons Dis. 2012;1(1):107-18. doi: 10.3233/JHD-2012-120021. J Huntingtons Dis. 2012. PMID: 23097680 Free PMC article.

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αB-Crystallin overexpression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease.

Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. Oliveira AO, et al. Among authors: muchowski pj. Hum Mol Genet. 2016 May 1;25(9):1677-89. doi: 10.1093/hmg/ddw028. Epub 2016 Feb 26. Hum Mol Genet. 2016. PMID: 26920069 Free PMC article.

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Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context.

Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. Sancenon V, et al. Among authors: muchowski pj. Hum Mol Genet. 2012 Jun 1;21(11):2432-49. doi: 10.1093/hmg/dds058. Epub 2012 Feb 21. Hum Mol Genet. 2012. PMID: 22357655 Free PMC article.

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Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease.

Kwan W, Magnusson A, Chou A, Adame A, Carson MJ, Kohsaka S, Masliah E, Möller T, Ransohoff R, Tabrizi SJ, Björkqvist M, Muchowski PJ. Kwan W, et al. Among authors: muchowski pj. J Neurosci. 2012 Jan 4;32(1):133-42. doi: 10.1523/JNEUROSCI.4846-11.2012. J Neurosci. 2012. PMID: 22219276 Free PMC article.

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Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.

Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. Zwilling D, et al. Among authors: muchowski jm, muchowski pj. Cell. 2011 Jun 10;145(6):863-74. doi: 10.1016/j.cell.2011.05.020. Cell. 2011. PMID: 21640374 Free PMC article.

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Disease-modifying pathways in neurodegeneration.

Finkbeiner S, Cuervo AM, Morimoto RI, Muchowski PJ. Finkbeiner S, et al. Among authors: muchowski pj. J Neurosci. 2006 Oct 11;26(41):10349-57. doi: 10.1523/JNEUROSCI.3829-06.2006. J Neurosci. 2006. PMID: 17035516 Free PMC article. Review. No abstract available.

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Cheng IH, et al. Among authors: muchowski pj. J Biol Chem. 2007 Aug 17;282(33):23818-28. doi: 10.1074/jbc.M701078200. Epub 2007 Jun 4. J Biol Chem. 2007. PMID: 17548355

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N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion.

Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM. Chen MZ, et al. Among authors: muchowski pj. J Huntingtons Dis. 2017;6(1):79-91. doi: 10.3233/JHD-160207. J Huntingtons Dis. 2017. PMID: 28339398

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Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules.

Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. Sontag EM, et al. Among authors: muchowski pj. J Huntingtons Dis. 2012;1(1):119-32. doi: 10.3233/JHD-2012-129004. J Huntingtons Dis. 2012. PMID: 24086178 Free PMC article.

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Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models.

Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. Sontag EM, et al. Among authors: muchowski pj. J Neurosci. 2012 Aug 8;32(32):11109-19. doi: 10.1523/JNEUROSCI.0895-12.2012. J Neurosci. 2012. PMID: 22875942 Free PMC article.

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