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Exploring 3-hydroxyflavone scaffolds as mushroom tyrosinase inhibitors: synthesis, X-ray crystallography, antimicrobial, fluorescence behaviour, structure-activity relationship and molecular modelling studies.
J Biomol Struct Dyn. 2021 Nov;39(18):7107-7122. doi: 10.1080/07391102.2020.1805364. Epub 2020 Aug 17.
J Biomol Struct Dyn. 2021.
PMID: 32799758
In due course and our approach to synthesize bioactive compounds, a series of varyingly substituted 3-hydroxyflavone derivatives (1-23) were synthesized in one-pot reaction and screened for in vitro against mushroom tyrosinase enzyme. ...Remarkably, the compound 2 (IC(50) …
In due course and our approach to synthesize bioactive compounds, a series of varyingly substituted 3-hydroxyflavone derivatives (1-2 …
Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure-activity relationship and molecular modelling simulations.
Mughal EU, Sadiq A, Ayub M, Naeem N, Javid A, Sumrra SH, Zafar MN, Khan BA, Malik FP, Ahmed I.
Mughal EU, et al.
J Biomol Struct Dyn. 2021 Oct;39(16):6154-6167. doi: 10.1080/07391102.2020.1803136. Epub 2020 Aug 5.
J Biomol Struct Dyn. 2021.
PMID: 32752941
The findings showed that all the synthesized target compounds (1-10) are potent dual inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes with varying IC(50) values. ...[Formula: see text]HIGHLIGHTS3-benzyloxyflavone analogues were designed, s …
The findings showed that all the synthesized target compounds (1-10) are potent dual inhibitors of acetylcholinesterase (AChE) and bu …
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