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Circumventing cellular immunity by miR142-mediated regulation sufficiently supports rAAV-delivered OVA expression without activating humoral immunity.
Xiao Y, Muhuri M, Li S, Qin W, Xu G, Luo L, Li J, Letizia AJ, Wang SK, Chan YK, Wang C, Fuchs SP, Wang D, Su Q, Nahid MA, Church GM, Farzan M, Yang L, Wei Y, Desrosiers RC, Mueller C, Tai PW, Gao G. Xiao Y, et al. Among authors: muhuri m. JCI Insight. 2019 May 21;5(13):e99052. doi: 10.1172/jci.insight.99052. JCI Insight. 2019. PMID: 31112525 Free PMC article.
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.
Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ Jr, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Chan YK, et al. Among authors: muhuri m. Sci Transl Med. 2021 Feb 10;13(580):eabd3438. doi: 10.1126/scitranslmed.abd3438. Sci Transl Med. 2021. PMID: 33568518 Free PMC article.
Novel Combinatorial MicroRNA-Binding Sites in AAV Vectors Synergistically Diminish Antigen Presentation and Transgene Immunity for Efficient and Stable Transduction.
Muhuri M, Zhan W, Maeda Y, Li J, Lotun A, Chen J, Sylvia K, Dasgupta I, Arjomandnejad M, Nixon T, Keeler AM, Manokaran S, He R, Su Q, Tai PWL, Gao G. Muhuri M, et al. Front Immunol. 2021 Apr 28;12:674242. doi: 10.3389/fimmu.2021.674242. eCollection 2021. Front Immunol. 2021. PMID: 33995418 Free PMC article.
Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells.
Arjomandnejad M, Sylvia K, Blackwood M, Nixon T, Tang Q, Muhuri M, Gruntman AM, Gao G, Flotte TR, Keeler AM. Arjomandnejad M, et al. Among authors: muhuri m. Mol Ther Methods Clin Dev. 2021 Oct 28;23:490-506. doi: 10.1016/j.omtm.2021.10.010. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34853797 Free PMC article.
Durability of transgene expression after rAAV gene therapy.
Muhuri M, Levy DI, Schulz M, McCarty D, Gao G. Muhuri M, et al. Mol Ther. 2022 Apr 6;30(4):1364-1380. doi: 10.1016/j.ymthe.2022.03.004. Epub 2022 Mar 10. Mol Ther. 2022. PMID: 35283274 Free PMC article. Review.
16 results