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Human immunome, bioinformatic analyses using HLA supermotifs and the parasite genome, binding assays, studies of human T cell responses, and immunization of HLA-A*1101 transgenic mice including novel adjuvants provide a foundation for HLA-A03 restricted CD8+T cell epitope based, adjuvanted vaccine protective against Toxoplasma gondii.
Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R. Cong H, et al. Among authors: mui ej. Immunome Res. 2010 Dec 3;6:12. doi: 10.1186/1745-7580-6-12. Immunome Res. 2010. PMID: 21129215 Free PMC article.
Delivery of antimicrobials into parasites.
Samuel BU, Hearn B, Mack D, Wender P, Rothbard J, Kirisits MJ, Mui E, Wernimont S, Roberts CW, Muench SP, Rice DW, Prigge ST, Law AB, McLeod R. Samuel BU, et al. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14281-6. doi: 10.1073/pnas.2436169100. Epub 2003 Nov 17. Proc Natl Acad Sci U S A. 2003. PMID: 14623959 Free PMC article.
Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo.
Mui EJ, Jacobus D, Milhous WK, Schiehser G, Hsu H, Roberts CW, Kirisits MJ, McLeod R. Mui EJ, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3463-7. doi: 10.1128/AAC.49.8.3463-3467.2005. Antimicrob Agents Chemother. 2005. PMID: 16048961 Free PMC article.
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents.
Muench SP, Prigge ST, McLeod R, Rafferty JB, Kirisits MJ, Roberts CW, Mui EJ, Rice DW. Muench SP, et al. Among authors: mui ej. Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):328-38. doi: 10.1107/S0907444906053625. Epub 2007 Feb 21. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17327670 Free PMC article.
Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids.
Welti R, Mui E, Sparks A, Wernimont S, Isaac G, Kirisits M, Roth M, Roberts CW, Botté C, Maréchal E, McLeod R. Welti R, et al. Biochemistry. 2007 Dec 4;46(48):13882-90. doi: 10.1021/bi7011993. Epub 2007 Nov 8. Biochemistry. 2007. PMID: 17988103 Free PMC article.
60 results