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The pathogenesis, prediction, and prevention of insulin-dependent diabetes mellitus.
Muir A, Schatz DA, Maclaren NK. Muir A, et al. Endocrinol Metab Clin North Am. 1992 Jun;21(2):199-219. Endocrinol Metab Clin North Am. 1992. PMID: 1612064 Review.
This knowledge has led to investigate use of a battery of immunologic, genetic, and metabolic tests for identifying people with prediabetes. ...
This knowledge has led to investigate use of a battery of immunologic, genetic, and metabolic tests for identifying people with predi …
Autoimmune diseases of the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis.
Muir A, Maclaren NK. Muir A, et al. Endocrinol Metab Clin North Am. 1991 Sep;20(3):619-44. Endocrinol Metab Clin North Am. 1991. PMID: 1935921 Review.
Autoimmunity directed against the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis can arise in isolation or as part of a polyglandular autoimmune syndrome. ...
Autoimmunity directed against the adrenal glands, parathyroid glands, gonads, and hypothalamic-pituitary axis can arise in isolation or as p …
Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison's disease.
Song YH, Connor EL, Muir A, She JX, Zorovich B, Derovanesian D, Maclaren N. Song YH, et al. J Clin Endocrinol Metab. 1994 May;78(5):1108-12. doi: 10.1210/jcem.78.5.7513715. J Clin Endocrinol Metab. 1994. PMID: 7513715
Recently, autoantibodies that bind a 55-kilodalton protein in the microsomal fraction of adrenal gland extracts identified to be the cytochrome P450 enzyme 21-hydroxylase have been found in Addisonian patient sera. ...Our findings should lead to the development of a
Recently, autoantibodies that bind a 55-kilodalton protein in the microsomal fraction of adrenal gland extracts identified to be the …
Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
Luo DF, Bui MM, Muir A, Maclaren NK, Thomson G, She JX. Luo DF, et al. Am J Hum Genet. 1995 Oct;57(4):911-9. Am J Hum Genet. 1995. PMID: 7573053 Free PMC article.
Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. ...Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida famili …
Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has bee …
Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies.
Deng GY, Muir A, Maclaren NK, She JX. Deng GY, et al. Am J Hum Genet. 1995 Feb;56(2):528-34. Am J Hum Genet. 1995. PMID: 7847389 Free PMC article.
LMP2 and LMP7, two subunits of the proteasomes encoded in the major histocompatibility complex, are speculated to play a role in the generation of endogenous peptides for presentation by class I molecules to cytotoxic T cells. ...A genomic polymorphism of LMP7 was f …
LMP2 and LMP7, two subunits of the proteasomes encoded in the major histocompatibility complex, are speculated to play a role in the …
Additive susceptibility to insulin-dependent diabetes conferred by HLA-DQB1 and insulin genes.
She JX, Bui MM, Tian XH, Muir A, Wakeland EK, Zorovich B, Zhang LP, Liu MC, Thomson G, Maclaren NK. She JX, et al. Autoimmunity. 1994;18(3):195-203. doi: 10.3109/08916939409007996. Autoimmunity. 1994. PMID: 7858104
However, a significant predisposing effect of DQB1*0201 could be demonstrated only after removal of the effects of DQB1*0302 and DQB1*0602. ...However, heterozygous genotypes 0302/X (X excludes 0201, 0302 and 0602) have a significantly lower predisposing risk. Simil …
However, a significant predisposing effect of DQB1*0201 could be demonstrated only after removal of the effects of DQB1*0302 and DQB1 …
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
Muir A, Peck A, Clare-Salzler M, Song YH, Cornelius J, Luchetta R, Krischer J, Maclaren N. Muir A, et al. J Clin Invest. 1995 Feb;95(2):628-34. doi: 10.1172/JCI117707. J Clin Invest. 1995. PMID: 7860747 Free PMC article.
We report here that intermittent immunizations with insulin or its metabolically inactive B-chain in incomplete Freund's adjuvant also prevent diabetes in NOD mice, whereas immunizations with A-chain insulin or with BSA do not. ...
We report here that intermittent immunizations with insulin or its metabolically inactive B-chain in incomplete Freund's adjuvant also preve …
High risk HLA-DR/DQ genotypes for IDD confer susceptibility to autoantibodies but DQB1*0602 does not prevent them.
Huang W, She JX, Muir A, Laskowska D, Zorovich B, Schatz D, Maclaren NK. Huang W, et al. J Autoimmun. 1994 Dec;7(6):889-97. doi: 10.1006/jaut.1994.1073. J Autoimmun. 1994. PMID: 7888045
The latter finding was similar to that in our patients with IDD, in that only two of them (0.5%) had a DQB1*0602 allele. In conclusion, HLA-encoded susceptibilities to disease-relevant autoantibody production and IDD are concordant with the susceptibility alleles, but disc …
The latter finding was similar to that in our patients with IDD, in that only two of them (0.5%) had a DQB1*0602 allele. In conclusio …
Intervention therapies for insulin-dependent diabetes.
Muir A, Schatz DA, Pozzilli P, MacLaren NK. Muir A, et al. Autoimmunity. 1993;16(4):301-10. doi: 10.3109/08916939309014650. Autoimmunity. 1993. PMID: 8025209 Review.
A wide variety of strategies are available and their choice should be dependent on the pathogenic stage of disease at which treatment is initiated. This stage-specific approach to prevention is discussed with a particular focus on those therapies that will soon be t
A wide variety of strategies are available and their choice should be dependent on the pathogenic stage of disease at which treatment
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