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Primary Aldosteronism and Obstructive Sleep Apnea: A Cross-Sectional Multi-Ethnic Study
Buffolo F, et al. Hypertension 2019. Among authors: Mulatero P. PMID 31679423
A correlation between aldosterone levels and apnea/hypopnea index was observed in white patients with PA (R(2)=0.225, P=0.016) but not in Chinese patients. Multinomial logistic regression confirmed a significant and independent association between plasma aldosterone levels and moderate to severe OSA diagnosis in white patients (odds ratio, 1.002; P=0.002). ...
A correlation between aldosterone levels and apnea/hypopnea index was observed in white patients with PA (R(2)=0.225, P=0.016) but no …
Predictors of recurrence of pheochromocytoma and paraganglioma: a multicenter study in Piedmont, Italy
Parasiliti-Caprino M, et al. Hypertens Res 2019. Among authors: Mulatero P. PMID 31586159
Multivariate analysis showed that genetic mutation (HR = 3.62; 95% CI 1.44-9.13; p = 0.006), younger age (HR = 0.97; 95% CI 0.95-0.99; p = 0.031) and larger tumor size (HR = 1.01; 95% CI 1.00-1.02; p = 0.015) were independently associated with a higher recurrence risk of pheochromocytoma and paraganglioma; in pheochromocytomas, genetic mutation (HR = 3.4; 95% CI 1.00-11.48; p = 0.049), younger age (HR = 0.97; 95% CI 0.94-0.99; p = 0.02), higher tumor size (HR = 1.01; 95% CI 1.00-1.03; p = 0.043) and PASS value (HR = 1.16; 95% CI 1.03-1.3; p = 0.011) were associated with recurrence. Moreover, tumor size was the only predictor of metastatic pheochromocytoma and paraganglioma (HR = 4.6; 95% CI 1.4-15.0; p = 0.012); tumor size (HR = 3.93; 95% CI 1.2-16.4; p = 0.026) and PASS value (HR = 1.27; 95% CI 1.06-1.53; p = 0.007) were predictors of metastatic pheochromocytoma. ...
Multivariate analysis showed that genetic mutation (HR = 3.62; 95% CI 1.44-9.13; p = 0.006), younger age (HR = 0.97; 95% CI 0.95-0.99 …
Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations
Ono Y, et al. J Clin Endocrinol Metab 2019. Among authors: Mulatero P. PMID 31789380
RESULTS: KCNJ5- and ATP2B3-mutated APAs had clear cell dominant features [KCNJ5: clear 59.8% (54.4%-64.6 %) vs. compact 40.2% (35.4%-45.6 %), P=0.0022; ATP2B3: clear 54.3% (48.2%-62.4 %) vs. compact 45.7% (37.6%-51.8 %), P=0.0696]. ...A significantly positive correlation of immunoreactivity was detected between CYP11B2 and CYP17A1 in tumor cells of KCNJ5-mutated APAs (P=0.0112; ρ=0.7237) , in contrast, significantly inverse correlation was detected in ATP1A1-mutated APAs (P=0.0025; ρ=-0.8667). ...
RESULTS: KCNJ5- and ATP2B3-mutated APAs had clear cell dominant features [KCNJ5: clear 59.8% (54.4%-64.6 %) vs. compact 40.2% (35.4%-45.6 %) …
Characterization and Gene Expression Analysis of Serum-Derived Extracellular Vesicles in Primary Aldosteronism
Burrello J, et al. Hypertension 2019. Among authors: Mulatero P. PMID 31230554
At nanoparticle tracking analysis, EVs concentration was 2.2× higher in patients with PA ( P=0.033) compared with EH and a significant correlation between EV number and serum aldosterone and potassium levels was identified. ...After unilateral adrenalectomy, EVs number and expression of CASP1 and EDN1 significantly decreased in patients with PA ( P<0.05). ...
At nanoparticle tracking analysis, EVs concentration was 2.2× higher in patients with PA ( P=0.033) compared with EH and a significan …
Urinary Metabolic Signature of Primary Aldosteronism: Gender and Subtype-Specific Alterations
Lana A, et al. Proteomics Clin Appl 2019 - Clinical Trial. Among authors: Mulatero P. PMID 30580498
RESULTS: Statistically significant changes (p < 0.05 ANOVA, Fc > 1.5) of metabolites involved in central carbon, energy, and nitrogen metabolism are identified, especially purine and pyrimidine nucleosides and precursors, and free amino acids. ...
RESULTS: Statistically significant changes (p < 0.05 ANOVA, Fc > 1.5) of metabolites involved in central carbon, energy, and ni …
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