Mulhearn DC - Search Results

1

Structural model of a complex between the heterotrimeric G protein, Gsalpha, and tubulin.

Layden BT, Saengsawang W, Donati RJ, Yang S, Mulhearn DC, Johnson ME, Rasenick MM. Layden BT, et al. Among authors: mulhearn dc. Biochim Biophys Acta. 2008 Jun;1783(6):964-73. doi: 10.1016/j.bbamcr.2008.02.017. Epub 2008 Mar 4. Biochim Biophys Acta. 2008. PMID: 18373982 Free PMC article.

2

Structure of dihydroorotase from Bacillus anthracis at 2.6 Å resolution.

Mehboob S, Mulhearn DC, Truong K, Johnson ME, Santarsiero BD. Mehboob S, et al. Among authors: mulhearn dc. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt 11):1432-5. doi: 10.1107/S1744309110037085. Epub 2010 Oct 27. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010. PMID: 21045288 Free PMC article.

3

Structural and functional analysis of two glutamate racemase isozymes from Bacillus anthracis and implications for inhibitor design.

May M, Mehboob S, Mulhearn DC, Wang Z, Yu H, Thatcher GR, Santarsiero BD, Johnson ME, Mesecar AD. May M, et al. Among authors: mulhearn dc. J Mol Biol. 2007 Aug 31;371(5):1219-37. doi: 10.1016/j.jmb.2007.05.093. Epub 2007 Jun 4. J Mol Biol. 2007. PMID: 17610893 Free PMC article.

4

Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Tipparaju SK, Mulhearn DC, Klein GM, Chen Y, Tapadar S, Bishop MH, Yang S, Chen J, Ghassemi M, Santarsiero BD, Cook JL, Johlfs M, Mesecar AD, Johnson ME, Kozikowski AP. Tipparaju SK, et al. Among authors: mulhearn dc. ChemMedChem. 2008 Aug;3(8):1250-68. doi: 10.1002/cmdc.200800047. ChemMedChem. 2008. PMID: 18663709 Free PMC article.

5

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings.

Lee H, Mittal A, Patel K, Gatuz JL, Truong L, Torres J, Mulhearn DC, Johnson ME. Lee H, et al. Among authors: mulhearn dc. Bioorg Med Chem. 2014 Jan 1;22(1):167-77. doi: 10.1016/j.bmc.2013.11.041. Epub 2013 Dec 1. Bioorg Med Chem. 2014. PMID: 24332657 Free PMC article.

6

Design, synthesis, and evaluation of oxyanion-hole selective inhibitor substituents for the S1 subsite of factor Xa.

Rumthao S, Lee O, Sheng Q, Fu W, Mulhearn DC, Crich D, Mesecar AD, Johnson ME. Rumthao S, et al. Among authors: mulhearn dc. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5165-70. doi: 10.1016/j.bmcl.2004.07.054. Bioorg Med Chem Lett. 2004. PMID: 15380220

7

Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Tipparaju SK, et al. Among authors: mulhearn dc. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3565-9. doi: 10.1016/j.bmcl.2008.05.004. Epub 2008 May 4. Bioorg Med Chem Lett. 2008. PMID: 18499454 Free PMC article.

8

Regioselective covalent modification of hemoglobin in search of antisickling agents.

Park S, Hayes BL, Marankan F, Mulhearn DC, Wanna L, Mesecar AD, Santarsiero BD, Johnson ME, Venton DL. Park S, et al. Among authors: mulhearn dc. J Med Chem. 2003 Mar 13;46(6):936-53. doi: 10.1021/jm020361k. J Med Chem. 2003. PMID: 12620071

9

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.

Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mulhearn dc. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. doi: 10.1016/j.bmcl.2008.08.082. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18796354 Free PMC article.

10

Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation.

Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mulhearn dc. J Med Chem. 2010 Jul 8;53(13):4968-79. doi: 10.1021/jm1004489. J Med Chem. 2010. PMID: 20527968 Free PMC article.

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