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Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?
Schlegel JG, Tahoun M, Seidinger A, Voss JH, Kuschak M, Kehraus S, Schneider M, Matthey M, Fleischmann BK, König GM, Wenzel D, Müller CE. Schlegel JG, et al. Among authors: muller ce. ACS Pharmacol Transl Sci. 2021 Feb 19;4(2):888-897. doi: 10.1021/acsptsci.1c00021. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2021. PMID: 33860209
Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin.
Carnero Corrales MA, Zinken S, Konstantinidis G, Rafehi M, Abdelrahman A, Wu YW, Janning P, Müller CE, Laraia L, Waldmann H. Carnero Corrales MA, et al. Among authors: muller ce. Cell Chem Biol. 2021 Mar 9:S2451-9456(21)00102-1. doi: 10.1016/j.chembiol.2021.02.017. Online ahead of print. Cell Chem Biol. 2021. PMID: 33725479
Synergistic Impact of Systolic Blood Pressure and Perfusion Status on Mortality in Acute Heart Failure.
Rossello X, Bueno H, Gil V, Jacob J, Martín-Sánchez FJ, Llorens P, Herrero Puente P, Alquézar-Arbé A, Espinosa B, Raposeiras-Roubín S, Müller CE, Mebazaa A, Maggioni AP, Pocock S, Chioncel O, Miró Ò; ICA-SEMES Research Group*. Rossello X, et al. Among authors: muller ce. Circ Heart Fail. 2021 Mar;14(3):e007347. doi: 10.1161/CIRCHEARTFAILURE.120.007347. Epub 2021 Mar 8. Circ Heart Fail. 2021. PMID: 33677977
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.
Breidenbach J, Lemke C, Pillaiyar T, Schäkel L, Al Hamwi G, Diett M, Gedschold R, Geiger N, Lopez V, Mirza S, Namasivayam V, Schiedel AC, Sylvester K, Thimm D, Vielmuth C, Phuong Vu L, Zyulina M, Bodem J, Gütschow M, Müller CE. Breidenbach J, et al. Among authors: muller ce. Angew Chem Int Ed Engl. 2021 Mar 3:10.1002/anie.202016961. doi: 10.1002/anie.202016961. Online ahead of print. Angew Chem Int Ed Engl. 2021. PMID: 33655614 Free PMC article.
An experimental strategy to probe Gq contribution to signal transduction in living cells.
Patt J, Alenfelder J, Pfeil EM, Voss JH, Merten N, Eryilmaz F, Heycke N, Rick U, Inoue A, Kehraus S, Deupi X, Müller CE, König GM, Crüsemann M, Kostenis E. Patt J, et al. Among authors: muller ce. J Biol Chem. 2021 Feb 24;296:100472. doi: 10.1016/j.jbc.2021.100472. Online ahead of print. J Biol Chem. 2021. PMID: 33639168 Free PMC article.
A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice.
Wolf K, Kühn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, Ständer S, Ectors P, Zahn D, Riedel YK, Thimm D, Müller CE, Kretschmann S, Kremer AN, Chien D, Limjunyawong N, Peng Q, Dong X, Kolkhir P, Scheffel J, Søgaard ML, Weigmann B, Neurath MF, Hawro T, Metz M, Fischer MJM, Kremer AE. Wolf K, et al. Among authors: muller ce. J Allergy Clin Immunol. 2021 Feb 20:S0091-6749(21)00229-3. doi: 10.1016/j.jaci.2020.12.655. Online ahead of print. J Allergy Clin Immunol. 2021. PMID: 33617860
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