Muller GW - Search Results

1

Alpha-fluoro-substituted thalidomide analogues.

Man HW, Corral LG, Stirling DI, Muller GW. Man HW, et al. Among authors: muller gw. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3415-7. doi: 10.1016/s0960-894x(03)00778-9. Bioorg Med Chem Lett. 2003. PMID: 14505639

2

Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs.

Schafer PH, Gandhi AK, Loveland MA, Chen RS, Man HW, Schnetkamp PP, Wolbring G, Govinda S, Corral LG, Payvandi F, Muller GW, Stirling DI. Schafer PH, et al. Among authors: muller gw. J Pharmacol Exp Ther. 2003 Jun;305(3):1222-32. doi: 10.1124/jpet.102.048496. Epub 2003 Mar 20. J Pharmacol Exp Ther. 2003. PMID: 12649301

3

Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner.

Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI. Payvandi F, et al. Among authors: muller gw. Cell Immunol. 2004 Aug;230(2):81-8. doi: 10.1016/j.cellimm.2004.09.003. Cell Immunol. 2004. PMID: 15598423

4

Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.

Man HW, Schafer P, Wong LM, Patterson RT, Corral LG, Raymon H, Blease K, Leisten J, Shirley MA, Tang Y, Babusis DM, Chen R, Stirling D, Muller GW. Man HW, et al. Among authors: muller gw. J Med Chem. 2009 Mar 26;52(6):1522-4. doi: 10.1021/jm900210d. J Med Chem. 2009. PMID: 19256507

5

Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.

Ruchelman AL, Man HW, Zhang W, Chen R, Capone L, Kang J, Parton A, Corral L, Schafer PH, Babusis D, Moghaddam MF, Tang Y, Shirley MA, Muller GW. Ruchelman AL, et al. Among authors: muller gw. Bioorg Med Chem Lett. 2013 Jan 1;23(1):360-5. doi: 10.1016/j.bmcl.2012.10.071. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2013. PMID: 23168019

6

Thalidomide and its analogues have distinct and opposing effects on TNF-alpha and TNFR2 during co-stimulation of both CD4(+) and CD8(+) T cells.

Marriott JB, Clarke IA, Dredge K, Muller G, Stirling D, Dalgleish AG. Marriott JB, et al. Clin Exp Immunol. 2002 Oct;130(1):75-84. doi: 10.1046/j.1365-2249.2002.01954.x. Clin Exp Immunol. 2002. PMID: 12296856 Free PMC article. Clinical Trial.

7

Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.

Muller GW, Corral LG, Shire MG, Wang H, Moreira A, Kaplan G, Stirling DI. Muller GW, et al. J Med Chem. 1996 Aug 16;39(17):3238-40. doi: 10.1021/jm9603328. J Med Chem. 1996. PMID: 8765505 No abstract available.

8

Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity.

Corral LG, Muller GW, Moreira AL, Chen Y, Wu M, Stirling D, Kaplan G. Corral LG, et al. Among authors: muller gw. Mol Med. 1996 Jul;2(4):506-15. Mol Med. 1996. PMID: 8827720 Free PMC article.

9

Thalidomide analogs and PDE4 inhibition.

Muller GW, Shire MG, Wong LM, Corral LG, Patterson RT, Chen Y, Stirling DI. Muller GW, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. doi: 10.1016/s0960-894x(98)00475-2. Bioorg Med Chem Lett. 1998. PMID: 9873600

10

Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.

Corral LG, Haslett PA, Muller GW, Chen R, Wong LM, Ocampo CJ, Patterson RT, Stirling DI, Kaplan G. Corral LG, et al. Among authors: muller gw. J Immunol. 1999 Jul 1;163(1):380-6. J Immunol. 1999. PMID: 10384139

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