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Mitochondrial iron-sulfur cluster biogenesis from molecular understanding to clinical disease.
Alfadhel M, Nashabat M, Abu Ali Q, Hundallah K. Alfadhel M, et al. Neurosciences (Riyadh). 2017 Jan;22(1):4-13. doi: 10.17712/nsj.2017.1.20160542. Neurosciences (Riyadh). 2017. PMID: 28064324 Free PMC article. Review.
Located in the mitochondria, cytosol, endoplasmic reticulum and nucleus, they contribute to various core cellular functions. Until recently, only a few human diseases related to mitochondrial ISC biogenesis defects have been described. Such diseases include Friedreich atax …
Located in the mitochondria, cytosol, endoplasmic reticulum and nucleus, they contribute to various core cellular functions. Until recently, …
Mitochondrial proteomics--a tool for the study of metabolic disorders.
Gregersen N, Hansen J, Palmfeldt J. Gregersen N, et al. J Inherit Metab Dis. 2012 Jul;35(4):715-26. doi: 10.1007/s10545-012-9480-3. Epub 2012 Apr 17. J Inherit Metab Dis. 2012. PMID: 22526845 Review.
These responses range from induction of protein quality control and antioxidant systems to mitochondria elimination and cell death. Mitochondrial dysfunctions are involved in pathologies associated with many diseases, for example metabolic disorders, diabetes, cance …
These responses range from induction of protein quality control and antioxidant systems to mitochondria elimination and cell death. Mitoc …