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The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation.
Mummaneni P, Yates P, Simpson J, Rose J, Turker MS. Mummaneni P, et al. Nucleic Acids Res. 1998 Nov 15;26(22):5163-9. doi: 10.1093/nar/26.22.5163. Nucleic Acids Res. 1998. PMID: 9801314 Free PMC article.
A cis-acting element accounts for a conserved methylation pattern upstream of the mouse adenine phosphoribosyltransferase gene.
Mummaneni P, Bishop PL, Turker MS. Mummaneni P, et al. J Biol Chem. 1993 Jan 5;268(1):552-8. J Biol Chem. 1993. PMID: 8416960
., Mummaneni, P., and Bishop, P.L. (1991) Somat. Cell Mol. Genet. 17, 151-157). To examine the molecular basis of the conserved methylation pattern, a plasmid-based deletion analysis was conducted by removing and rearranging specific portions of the upstream …
., Mummaneni, P., and Bishop, P.L. (1991) Somat. Cell Mol. Genet. 17, 151-157). To examine the molecular basis of the c …
Epigenetic gene inactivation induced by a cis-acting methylation center.
Mummaneni P, Walker KA, Bishop PL, Turker MS. Mummaneni P, et al. J Biol Chem. 1995 Jan 13;270(2):788-92. doi: 10.1074/jbc.270.2.788. J Biol Chem. 1995. PMID: 7822312
The cis-acting element used is an 838-base pair fragment that was shown previously to provide a de novo methylation signal (Mummaneni, P., Bishop, P. ...
The cis-acting element used is an 838-base pair fragment that was shown previously to provide a de novo methylation signal (Mummaneni
The mouse APRT gene as a model for studying epigenetic gene inactivation.
Turker MS, Mummaneni P, Cooper GE. Turker MS, et al. Adv Exp Med Biol. 1994;370:647-52. doi: 10.1007/978-1-4615-2584-4_134. Adv Exp Med Biol. 1994. PMID: 7660987 No abstract available.
Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87).
Ganguly S, Mummaneni P, Steinbach PJ, Klein DC, Coon SL. Ganguly S, et al. J Biol Chem. 2001 Dec 14;276(50):47239-47. doi: 10.1074/jbc.M107222200. Epub 2001 Sep 14. J Biol Chem. 2001. PMID: 11559708
A Multicenter Study of the Presentation, Treatment, and Outcomes of Cervical Dural Tears.
O'Neill KR, Fehlings MG, Mroz TE, Smith ZA, Hsu WK, Kanter AS, Steinmetz MP, Arnold PM, Mummaneni PV, Chou D, Nassr A, Qureshi SA, Cho SK, Baird EO, Smith JS, Shaffrey C, Tannoury CA, Tannoury T, Gokaslan ZL, Gum JL, Hart RA, Isaacs RE, Sasso RC, Bumpass DB, Bydon M, Corriveau M, De Giacomo AF, Derakhshan A, Jobse BC, Lubelski D, Lee S, Massicotte EM, Pace JR, Smith GA, Than KD, Riew KD. O'Neill KR, et al. Global Spine J. 2017 Apr;7(1 Suppl):58S-63S. doi: 10.1177/2192568216688186. Epub 2017 Apr 1. Global Spine J. 2017. PMID: 28451493 Free PMC article.
There were statistical improvements (P < .05) in mJOA and NuC scores, but not NDI or SF36 scores. No specific baseline or operative factors were found to be associated with the occurrence of dural tears. ...

There were statistical improvements (P < .05) in mJOA and NuC scores, but not NDI or SF36 scores. No specific baseline or operativ

Treatment of the Fractional Curve of Adult Scoliosis With Circumferential Minimally Invasive Surgery Versus Traditional, Open Surgery: An Analysis of Surgical Outcomes.
Chou D, Mummaneni P, Anand N, Nunley P, La Marca F, Fu KM, Fessler R, Park P, Wang M, Than K, Nguyen S, Uribe J, Zavatsky J, Deviren V, Kanter A, Okonkwo D, Eastlack R, Mundis G; International Spine Study Group. Chou D, et al. Global Spine J. 2018 Dec;8(8):827-833. doi: 10.1177/2192568218775069. Epub 2018 May 10. Global Spine J. 2018. PMID: 30560035 Free PMC article.
Open had more posterior decompressions (80% vs 22.2%, P < .001). Both groups had similar preoperative (Visual Analogue Scale [VAS] leg 6.1 cMIS and 5.4 open) and postoperative (VAS leg 1.6 cMIS and 3.1 open) leg pain. ...

Open had more posterior decompressions (80% vs 22.2%, P < .001). Both groups had similar preoperative (Visual Analogue Scale [VAS]

Laminoplasty versus laminectomy with posterior spinal fusion for multilevel cervical spondylotic myelopathy: influence of cervical alignment on outcomes.
Lau D, Winkler EA, Than KD, Chou D, Mummaneni PV. Lau D, et al. J Neurosurg Spine. 2017 Nov;27(5):508-517. doi: 10.3171/2017.4.SPINE16831. Epub 2017 Sep 1. J Neurosurg Spine. 2017. PMID: 28862572

Laminoplasty cases were associated with less blood loss (196.6 vs 325.0 ml, p < 0.001) and trended toward shorter hospital stays (3.5 vs 4.3 days, p = 0.054). ...For laminoplasty, there was a significant trend for lower pain incidence (p = 0.010) and VAS n

Laminoplasty cases were associated with less blood loss (196.6 vs 325.0 ml, p < 0.001) and trended toward shorter hospital stays (

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