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Multitargeted cancer prevention by quercetin.
Murakami A, Ashida H, Terao J. Murakami A, et al. Cancer Lett. 2008 Oct 8;269(2):315-25. doi: 10.1016/j.canlet.2008.03.046. Epub 2008 May 7. Cancer Lett. 2008. PMID: 18467024 Review.
Quercetin is commonly present as a glycoside and is converted to glucuronide/sulfate conjugates during intestinal absorption and only conjugated metabolites are therefore found in circulating blood. ...Dietary quercetin is, therefore, a promising agent for cancer pr …
Quercetin is commonly present as a glycoside and is converted to glucuronide/sulfate conjugates during intestinal absorption and only …
Screening of edible Japanese plants for suppressive effects on phorbol ester-induced superoxide generation in differentiated HL-60 cells and AS52 cells.
Kim HW, Murakami A, Nakamura Y, Ohigashi H. Kim HW, et al. Among authors: murakami a. Cancer Lett. 2002 Feb 8;176(1):7-16. doi: 10.1016/s0304-3835(01)00735-2. Cancer Lett. 2002. PMID: 11790448
However, there are few known reports of a convenient bioassay to detect cellular XOD activity. We tested several cell lines, and found that AS52, from Chinese hamster ovary cells, produced a significant level of O(2)(-) in response to 12-O-tetradecanoylphorbol 13-ac …
However, there are few known reports of a convenient bioassay to detect cellular XOD activity. We tested several cell lines, and foun …
Rapid oxidation of dichlorodihydrofluorescin with heme and hemoproteins: formation of the fluorescein is independent of the generation of reactive oxygen species.
Ohashi T, Mizutani A, Murakami A, Kojo S, Ishii T, Taketani S. Ohashi T, et al. Among authors: murakami a. FEBS Lett. 2002 Jan 30;511(1-3):21-7. doi: 10.1016/s0014-5793(01)03262-8. FEBS Lett. 2002. PMID: 11821042
Treatment of HeLa cells with hemin or metalloporphyrins resulted in a rapid oxidation of DCFH in a time- and dose-dependent manner. This oxidation was inhibited by treatment of the cells with a large amount of superoxide dismutase and catalase, which is diffe …
Treatment of HeLa cells with hemin or metalloporphyrins resulted in a rapid oxidation of DCFH in a time- and dose-dependent ma …
Further investigation of the modifying effect of various chemopreventive agents on apoptosis and cell proliferation in human colon cancer cells.
Zheng Q, Hirose Y, Yoshimi N, Murakami A, Koshimizu K, Ohigashi H, Sakata K, Matsumoto Y, Sayama Y, Mori H. Zheng Q, et al. Among authors: murakami a. J Cancer Res Clin Oncol. 2002 Oct;128(10):539-46. doi: 10.1007/s00432-002-0373-y. Epub 2002 Sep 17. J Cancer Res Clin Oncol. 2002. PMID: 12384797
Then, induction of apoptosis was detected by means of a DNA fragmentation assay, a quantitative enzyme immunoassay, and morphological analysis using 4-diamidino-2-phenylindole staining. ...RESULTS: AUR, NOB, I3C, ACA, and ACE had apoptosis-inducing effects in a
Then, induction of apoptosis was detected by means of a DNA fragmentation assay, a quantitative enzyme immunoassay, and morpho …
Synergistic suppression of superoxide and nitric oxide generation from inflammatory cells by combined food factors.
Murakami A, Takahashi D, Koshimizu K, Ohigashi H. Murakami A, et al. Mutat Res. 2003 Feb-Mar;523-524:151-61. doi: 10.1016/s0027-5107(02)00331-7. Mutat Res. 2003. PMID: 12628513
In contrast to chemopreventive strategies using individual agents, a combination of specified compounds may be effectual to achieve desirable results with higher efficacy and lower toxicity. ...L-N(G)-Monomethyl-L-arginine (L-NMMA), a synthetic inducible nitric oxid …
In contrast to chemopreventive strategies using individual agents, a combination of specified compounds may be effectual to achieve d …
Search for Naturally-occurring Antioxidative Chemopreventors on the Basis of the Involvement of Leukocyte-derived Reactive Oxygen Species in Carcinogenesis.
Nakamura Y, Murakami A, Ohigashi H. Nakamura Y, et al. Among authors: murakami a. Asian Pac J Cancer Prev. 2000;1(2):115-120. Asian Pac J Cancer Prev. 2000. PMID: 12718677
We have been continuously working on the identification and characterization of chemopreventive phytochemicals extracted from a diverse range of edible plants. Recently, we have utilized a convenient assay, the tumor promoter-induced superoxide generation test, with …
We have been continuously working on the identification and characterization of chemopreventive phytochemicals extracted from a diver …
Effects of selected food factors with chemopreventive properties on combined lipopolysaccharide- and interferon-gamma-induced IkappaB degradation in RAW264.7 macrophages.
Murakami A, Matsumoto K, Koshimizu K, Ohigashi H. Murakami A, et al. Cancer Lett. 2003 May 30;195(1):17-25. doi: 10.1016/s0304-3835(03)00058-2. Cancer Lett. 2003. PMID: 12767507
Degradation of IkappaB (IkappaB) is a key step for nuclear factor-kappaB (NF-kappaB)-induced transcription of certain proinflammatory genes, including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. ...
Degradation of IkappaB (IkappaB) is a key step for nuclear factor-kappaB (NF-kappaB)-induced transcription of certain proinflammatory …
Characteristic rat tissue accumulation of nobiletin, a chemopreventive polymethoxyflavonoid, in comparison with luteolin.
Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, Hosotani K, Kawahara S, Matsuoka Y. Murakami A, et al. Biofactors. 2002;16(3-4):73-82. doi: 10.1002/biof.5520160303. Biofactors. 2002. PMID: 14530595
Nobiletin (NOB), a polymethoxyflavonoid, is an effective anti-inflammatory and chemopreventive phytochemical found in citrus fruits. ...In the digestive organs, NOB showed a notable tendency for localizing into the mucous membrane and muscularis from 1 to 4 hours, i …
Nobiletin (NOB), a polymethoxyflavonoid, is an effective anti-inflammatory and chemopreventive phytochemical found in citrus fruits. …
Suppressive effects of natural and synthetic agents on dextran sulfate sodium-induced interleukin-1beta release from murine peritoneal macrophages.
Kwon KH, Murakami A, Ohigashi H. Kwon KH, et al. Among authors: murakami a. Biosci Biotechnol Biochem. 2004 Feb;68(2):436-9. doi: 10.1271/bbb.68.436. Biosci Biotechnol Biochem. 2004. PMID: 14981311
We examined the suppressive effects of a total of 39 synthetic or natural compounds on dextran sulfate sodium-induced IL-1beta production in murine peritoneal macrophages. ...
We examined the suppressive effects of a total of 39 synthetic or natural compounds on dextran sulfate sodium-induced IL-1beta produc …
Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice.
Murakami A, Tanaka T, Lee JY, Surh YJ, Kim HW, Kawabata K, Nakamura Y, Jiwajinda S, Ohigashi H. Murakami A, et al. Int J Cancer. 2004 Jul 1;110(4):481-90. doi: 10.1002/ijc.20175. Int J Cancer. 2004. PMID: 15122579
In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. A single topical pretreatment to mouse skin (2 micromol) 24 hr before application of dimethylbenz[ …
In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a convention …
1,412 results
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