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Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice.
Kim M, Miyamoto S, Yasui Y, Oyama T, Murakami A, Tanaka T. Kim M, et al. Among authors: murakami a. Int J Cancer. 2009 Jan 15;124(2):264-71. doi: 10.1002/ijc.23923. Int J Cancer. 2009. PMID: 19003968
In Exp. 1, a total of 85 male ICR mice were initiated using a single intraperitoneal (i.p.) injection with azoxymethane (AOM, 10 mg/kg bw) and promoted by 1.5% dextran sulfate sodium (DSS) in drinking water for 7 days for rapid induction of colonic neoplasms. ...In …
In Exp. 1, a total of 85 male ICR mice were initiated using a single intraperitoneal (i.p.) injection with azoxymethane (AOM, …
Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice.
Sung B, Murakami A, Oyajobi BO, Aggarwal BB. Sung B, et al. Among authors: murakami a. Cancer Res. 2009 Feb 15;69(4):1477-84. doi: 10.1158/0008-5472.CAN-08-3249. Epub 2009 Feb 3. Cancer Res. 2009. PMID: 19190327 Retracted.
In the present report, the potential of zerumbone, a sesquiterpene derived from subtropical ginger, to modulate osteoclastogenesis induced by RANKL and breast cancer was examined. ...We found that zerumbone decreased osteolysis in a dose-dependent manner in MDA-MB-2 …
In the present report, the potential of zerumbone, a sesquiterpene derived from subtropical ginger, to modulate osteoclastogenesis in …
Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.
Takada Y, Murakami A, Aggarwal BB. Takada Y, et al. Among authors: murakami a. Oncogene. 2005 Oct 20;24(46):6957-69. doi: 10.1038/sj.onc.1208845. Oncogene. 2005. PMID: 16007145
Interestingly, alpha-humulene, a structural analogue of zerumbone lacking the carbonyl group, was completely inactive. Besides being inducible, constitutively active NF-kappaB was also inhibited. ...Overall, our results indicated that zerumbone inhibits the activation of N …
Interestingly, alpha-humulene, a structural analogue of zerumbone lacking the carbonyl group, was completely inactive. Besides being …
Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo.
Sehrawat A, Arlotti JA, Murakami A, Singh SV. Sehrawat A, et al. Among authors: murakami a. Breast Cancer Res Treat. 2012 Nov;136(2):429-41. doi: 10.1007/s10549-012-2280-5. Epub 2012 Oct 6. Breast Cancer Res Treat. 2012. PMID: 23053663 Free PMC article.
The present study was undertaken to determine the anticancer efficacy of zerumbone (ZER), a sesquiterpene from subtropical ginger, against human breast cancer cells in vitro and in vivo. ZER treatment caused a dose-dependent decrease in viability of MCF-7 and MDA-MB …
The present study was undertaken to determine the anticancer efficacy of zerumbone (ZER), a sesquiterpene from subtropical ginger, ag …
Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.
Shin JW, Ohnishi K, Murakami A, Lee JS, Kundu JK, Na HK, Ohigashi H, Surh YJ. Shin JW, et al. Among authors: murakami a. Cancer Prev Res (Phila). 2011 Jun;4(6):860-70. doi: 10.1158/1940-6207.CAPR-10-0354. Epub 2011 Mar 2. Cancer Prev Res (Phila). 2011. PMID: 21367956
Zerumbone, a sesquiterpene derived from tropical ginger, contains an electrophilic α,β-unsaturated carbonyl moiety and was found to suppress chemically induced papilloma formation in mouse skin. ...Treatment of mouse epidermal JB6 cells with zerumbone caused a marke …
Zerumbone, a sesquiterpene derived from tropical ginger, contains an electrophilic α,β-unsaturated carbonyl moiety and was found to s …
Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway.
Xian M, Ito K, Nakazato T, Shimizu T, Chen CK, Yamato K, Murakami A, Ohigashi H, Ikeda Y, Kizaki M. Xian M, et al. Among authors: murakami a. Cancer Sci. 2007 Jan;98(1):118-26. doi: 10.1111/j.1349-7006.2006.00362.x. Cancer Sci. 2007. PMID: 17129359
ZER was also found to induce the cleavage of Bid, a mediator that is known to connect the Fas/CD95 cell death receptor to the mitochondrial apoptosis pathway. ...ZER also triggered a release of cytochrome c into the cytoplasm. Both antagonistic anti-Fas antibody ZB4 …
ZER was also found to induce the cleavage of Bid, a mediator that is known to connect the Fas/CD95 cell death receptor to the mitocho …
Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib.
Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Okamoto T, Murakami A, Maehara Y, Kitajima S. Edagawa M, et al. Among authors: murakami a. J Biol Chem. 2014 Aug 1;289(31):21544-61. doi: 10.1074/jbc.M114.558890. Epub 2014 Jun 17. J Biol Chem. 2014. PMID: 24939851 Free PMC article.
Death receptor 5 (DR5) is a death domain-containing transmembrane receptor that triggers cell death upon binding to its ligand, TNF-related apoptosis-inducing ligand (TRAIL), and a combination of TRAIL and agents that increase the expression of DR5 is expected to be …
Death receptor 5 (DR5) is a death domain-containing transmembrane receptor that triggers cell death upon binding to its ligand, TNF-r …
1'-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappaB activation.
Ichikawa H, Murakami A, Aggarwal BB. Ichikawa H, et al. Among authors: murakami a. Mol Cancer Res. 2006 Apr;4(4):275-81. doi: 10.1158/1541-7786.MCR-05-0227. Mol Cancer Res. 2006. PMID: 16603641
A member of the tumor necrosis factor superfamily, receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL), has been shown to play a critical role in osteoclast formation and bone resorption. Thus, agents that suppress RANKL signaling have a po
A member of the tumor necrosis factor superfamily, receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL), has been s
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.
Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Sandur SK, et al. Among authors: murakami a. Carcinogenesis. 2007 Aug;28(8):1765-73. doi: 10.1093/carcin/bgm123. Epub 2007 May 23. Carcinogenesis. 2007. PMID: 17522064
Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (Cur), such as demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumin (THC) and turmerones, modulate inflammatory signaling …
Curcumin, a component of turmeric (Curcuma longa), has been shown to exhibit chemopreventive activity. Whether analogs of curcumin (C …
Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.
Ichikawa H, Takada Y, Murakami A, Aggarwal BB. Ichikawa H, et al. Among authors: murakami a. J Immunol. 2005 Jun 1;174(11):7383-92. doi: 10.4049/jimmunol.174.11.7383. J Immunol. 2005. PMID: 15905586
1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of the commonly used ethno-medicinal plant Languas galanga, has been found to suppress chemical- and virus-induced tumor initiation and promotion through a poorly understood mechanism. ...We found that ACA suppresse …
1'-Acetoxychavicol acetate (ACA), extracted from rhizomes of the commonly used ethno-medicinal plant Languas galanga, has been found to supp …
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