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High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
Johnston MJ, Nikolic A, Ninkovic N, Guilhamon P, Cavalli FMG, Seaman S, Zemp FJ, Lee J, Abdelkareem A, Ellestad K, Murison A, Kushida MM, Coutinho FJ, Ma Y, Mungall AJ, Moore R, Marra MA, Taylor MD, Dirks PB, Pugh TJ, Morrissy S, St Croix B, Mahoney DJ, Lupien M, Gallo M. Johnston MJ, et al. Among authors: murison a. Genome Res. 2019 Aug;29(8):1211-1222. doi: 10.1101/gr.246520.118. Epub 2019 Jun 27. Genome Res. 2019. PMID: 31249064 Free PMC article.
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.
Gallo M, Coutinho FJ, Vanner RJ, Gayden T, Mack SC, Murison A, Remke M, Li R, Takayama N, Desai K, Lee L, Lan X, Park NI, Barsyte-Lovejoy D, Smil D, Sturm D, Kushida MM, Head R, Cusimano MD, Bernstein M, Clarke ID, Dick JE, Pfister SM, Rich JN, Arrowsmith CH, Taylor MD, Jabado N, Bazett-Jones DP, Lupien M, Dirks PB. Gallo M, et al. Among authors: murison a. Cancer Cell. 2015 Dec 14;28(6):715-729. doi: 10.1016/j.ccell.2015.10.005. Epub 2015 Nov 25. Cancer Cell. 2015. PMID: 26626085 Free article.
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Bahr C, von Paleske L, Uslu VV, Remeseiro S, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F. Bahr C, et al. Among authors: murison a. Nature. 2018 Jan 25;553(7689):515-520. doi: 10.1038/nature25193. Epub 2018 Jan 17. Nature. 2018. PMID: 29342133
Characterization of inv(3) cell line OCI-AML-20 with stroma-dependent CD34 expression.
Luciani GM, Xie L, Dilworth D, Tierens A, Moskovitz Y, Murison A, Szewczyk MM, Mitchell A, Lupien M, Shlush L, Dick JE, Arrowsmith CH, Barsyte-Lovejoy D, Minden MD. Luciani GM, et al. Among authors: murison a. Exp Hematol. 2019 Jan;69:27-36. doi: 10.1016/j.exphem.2018.10.006. Epub 2018 Oct 22. Exp Hematol. 2019. PMID: 30352278 Free article.
Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.
Lima-Fernandes E, Murison A, da Silva Medina T, Wang Y, Ma A, Leung C, Luciani GM, Haynes J, Pollett A, Zeller C, Duan S, Kreso A, Barsyte-Lovejoy D, Wouters BG, Jin J, Carvalho DD, Lupien M, Arrowsmith CH, O'Brien CA. Lima-Fernandes E, et al. Among authors: murison a. Nat Commun. 2019 Mar 29;10(1):1436. doi: 10.1038/s41467-019-09309-4. Nat Commun. 2019. PMID: 30926792 Free PMC article.
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.
Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Zhou S, et al. Among authors: murison a. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. Nat Commun. 2020. PMID: 31974375 Free PMC article.
Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer.
Deblois G, Tonekaboni SAM, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, Ba-Alawi W, Cescon DW, Arrowsmith CH, De Carvalho DD, Haibe-Kains B, Locasale JW, Park M, Lupien M. Deblois G, et al. Among authors: murison a. Cancer Discov. 2020 Sep;10(9):1312-1329. doi: 10.1158/2159-8290.CD-19-1493. Epub 2020 Jun 16. Cancer Discov. 2020. PMID: 32546577
The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization.
Takayama N, Murison A, Takayanagi SI, Arlidge C, Zhou S, Garcia-Prat L, Chan-Seng-Yue M, Zandi S, Gan OI, Boutzen H, Kaufmann KB, Trotman-Grant A, Schoof E, Kron K, Díaz N, Lee JJY, Medina T, De Carvalho DD, Taylor MD, Vaquerizas JM, Xie SZ, Dick JE, Lupien M. Takayama N, et al. Among authors: murison a. Cell Stem Cell. 2021 Mar 4;28(3):488-501.e10. doi: 10.1016/j.stem.2020.11.001. Epub 2020 Nov 25. Cell Stem Cell. 2021. PMID: 33242413 Free article.
41 results