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Repairing the myofilaments to heal the heart.
Frazier A, Murphy AM. Frazier A, et al. Among authors: murphy am. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H907-8. doi: 10.1152/ajpheart.00272.2007. Epub 2007 Apr 6. Am J Physiol Heart Circ Physiol. 2007. PMID: 17416606 Free article. No abstract available.
Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes.
Wijnker PJ, Foster DB, Tsao AL, Frazier AH, dos Remedios CG, Murphy AM, Stienen GJ, van der Velden J. Wijnker PJ, et al. Among authors: murphy am. Am J Physiol Heart Circ Physiol. 2013 Jan 15;304(2):H260-8. doi: 10.1152/ajpheart.00498.2012. Epub 2012 Nov 9. Am J Physiol Heart Circ Physiol. 2013. PMID: 23144315 Free PMC article.
Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativity.
Ramirez-Correa GA, Frazier AH, Zhu G, Zhang P, Rappold T, Kooij V, Bedja D, Snyder GA, Lugo-Fagundo NS, Hariharan R, Li Y, Shen X, Gao WD, Cingolani OH, Takimoto E, Foster DB, Murphy AM. Ramirez-Correa GA, et al. Among authors: murphy am. J Appl Physiol (1985). 2015 Jan 15;118(2):212-23. doi: 10.1152/japplphysiol.00463.2014. Epub 2014 Oct 16. J Appl Physiol (1985). 2015. PMID: 25324519 Free PMC article.
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.
Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J. Wijnker PJ, et al. Among authors: murphy am. J Mol Cell Cardiol. 2015 May;82:93-103. doi: 10.1016/j.yjmcc.2015.03.006. Epub 2015 Mar 11. J Mol Cell Cardiol. 2015. PMID: 25771144 Free PMC article.
The Burden of Early Phenotypes and the Influence of Wall Thickness in Hypertrophic Cardiomyopathy Mutation Carriers: Findings From the HCMNet Study.
Ho CY, Day SM, Colan SD, Russell MW, Towbin JA, Sherrid MV, Canter CE, Jefferies JL, Murphy AM, Cirino AL, Abraham TP, Taylor M, Mestroni L, Bluemke DA, Jarolim P, Shi L, Sleeper LA, Seidman CE, Orav EJ; HCMNet Investigators. Ho CY, et al. Among authors: murphy am. JAMA Cardiol. 2017 Apr 1;2(4):419-428. doi: 10.1001/jamacardio.2016.5670. JAMA Cardiol. 2017. PMID: 28241245 Free PMC article.
407 results