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IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis.
Murphy M, Docherty NG, Griffin B, Howlin J, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady HR, Furlong F, Godson C, Martin F. Murphy M, et al. J Am Soc Nephrol. 2008 Sep;19(9):1672-80. doi: 10.1681/ASN.2007101080. Epub 2008 May 28. J Am Soc Nephrol. 2008. PMID: 18508967 Free PMC article.
Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C. Börgeson E, et al. Among authors: murphy m. FASEB J. 2011 Sep;25(9):2967-79. doi: 10.1096/fj.11-185017. Epub 2011 May 31. FASEB J. 2011. PMID: 21628447
Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1.
Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C; GENIE Consortium. Brennan EP, et al. Among authors: murphy m. J Am Soc Nephrol. 2013 Mar;24(4):627-37. doi: 10.1681/ASN.2012060550. Epub 2013 Mar 21. J Am Soc Nephrol. 2013. PMID: 23520204 Free PMC article.
IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses.
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M. Corcoran JB, et al. Among authors: murphy m. Biochim Biophys Acta. 2013 Aug;1833(8):1969-78. doi: 10.1016/j.bbamcr.2013.03.027. Epub 2013 Apr 6. Biochim Biophys Acta. 2013. PMID: 23567938 Free article.
7,529 results