Murphy MP - Search Results

1

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

Minczuk M, Papworth MA, Miller JC, Murphy MP, Klug A. Minczuk M, et al. Among authors: murphy mp. Nucleic Acids Res. 2008 Jul;36(12):3926-38. doi: 10.1093/nar/gkn313. Epub 2008 May 29. Nucleic Acids Res. 2008. PMID: 18511461 Free PMC article.

2

Targeting peptide nucleic acid (PNA) oligomers to mitochondria within cells by conjugation to lipophilic cations: implications for mitochondrial DNA replication, expression and disease.

Muratovska A, Lightowlers RN, Taylor RW, Turnbull DM, Smith RA, Wilce JA, Martin SW, Murphy MP. Muratovska A, et al. Among authors: murphy mp. Nucleic Acids Res. 2001 May 1;29(9):1852-63. doi: 10.1093/nar/29.9.1852. Nucleic Acids Res. 2001. PMID: 11328868 Free PMC article.

3

How mitochondrial damage affects cell function.

James AM, Murphy MP. James AM, et al. Among authors: murphy mp. J Biomed Sci. 2002;9(6 Pt 1):475-87. doi: 10.1159/000064721. J Biomed Sci. 2002. PMID: 12372986 Review.

4

Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase.

Minczuk M, Papworth MA, Kolasinska P, Murphy MP, Klug A. Minczuk M, et al. Among authors: murphy mp. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19689-94. doi: 10.1073/pnas.0609502103. Epub 2006 Dec 14. Proc Natl Acad Sci U S A. 2006. PMID: 17170133 Free PMC article.

5

Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA.

Minczuk M, Kolasinska-Zwierz P, Murphy MP, Papworth MA. Minczuk M, et al. Among authors: murphy mp. Nat Protoc. 2010 Feb;5(2):342-56. doi: 10.1038/nprot.2009.245. Epub 2010 Feb 4. Nat Protoc. 2010. PMID: 20134433

6

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism.

Ryan DG, Yang M, Prag HA, Blanco GR, Nikitopoulou E, Segarra-Mondejar M, Powell CA, Young T, Burger N, Miljkovic JL, Minczuk M, Murphy MP, von Kriegsheim A, Frezza C. Ryan DG, et al. Among authors: murphy mp. Elife. 2021 Dec 23;10:e72593. doi: 10.7554/eLife.72593. Elife. 2021. PMID: 34939929 Free PMC article.

7

Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction.

Murphy MP. Murphy MP. Expert Opin Biol Ther. 2001 Sep;1(5):753-64. doi: 10.1517/14712598.1.5.753. Expert Opin Biol Ther. 2001. PMID: 11728211 Review.

8

Cell-penetrating peptides are excluded from the mitochondrial matrix.

Ross MF, Murphy MP. Ross MF, et al. Among authors: murphy mp. Biochem Soc Trans. 2004 Dec;32(Pt 6):1072-4. doi: 10.1042/BST0321072. Biochem Soc Trans. 2004. PMID: 15506968

9

Targeting antioxidants to mitochondria by conjugation to lipophilic cations.

Murphy MP, Smith RA. Murphy MP, et al. Annu Rev Pharmacol Toxicol. 2007;47:629-56. doi: 10.1146/annurev.pharmtox.47.120505.105110. Annu Rev Pharmacol Toxicol. 2007. PMID: 17014364 Review.

10

Mitochondrial targeting of quinones: therapeutic implications.

Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas AR, Porteous CM, Adlam VJ, Smith RA, Murphy MP. Cochemé HM, et al. Among authors: murphy mp. Mitochondrion. 2007 Jun;7 Suppl:S94-102. doi: 10.1016/j.mito.2007.02.007. Epub 2007 Mar 16. Mitochondrion. 2007. PMID: 17449335 Review.

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