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Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.
Mishra S, Sadagopan N, Dunkerly-Eyring B, Rodriguez S, Sarver DC, Ceddia RP, Murphy SA, Knutsdottir H, Jani VP, Ashok D, Oeing CU, O'Rourke B, Gangoiti JA, Sears DD, Wong GW, Collins S, Kass DA. Mishra S, et al. Among authors: murphy sa. J Clin Invest. 2021 Nov 1;131(21):e148798. doi: 10.1172/JCI148798. J Clin Invest. 2021. PMID: 34618683 Free PMC article.
PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C. Murphy SA, et al. Nat Commun. 2021 Mar 12;12(1):1648. doi: 10.1038/s41467-021-21957-z. Nat Commun. 2021. PMID: 33712605 Free PMC article.
Oxysterol misbalance critically contributes to Wilson disease pathogenesis.
Dev S, Muchenditsi A, Gottlieb A, Deme P, Murphy S, Gabrielson KL, Dong Y, Hughes R, Haughey NJ, Hamilton JP, Lutsenko S. Dev S, et al. Sci Adv. 2022 Oct 21;8(42):eadc9022. doi: 10.1126/sciadv.adc9022. Epub 2022 Oct 19. Sci Adv. 2022. PMID: 36260680 Free PMC article.
Heart neurons use clock genes to control myocyte proliferation.
Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C. Tampakakis E, et al. Sci Adv. 2021 Dec 3;7(49):eabh4181. doi: 10.1126/sciadv.abh4181. Epub 2021 Dec 1. Sci Adv. 2021. PMID: 34851661 Free PMC article.
Noncanonical Notch signals have opposing roles during cardiac development.
Miyamoto M, Andersen P, Sulistio E, Liu X, Murphy S, Kannan S, Nam L, Miyamoto W, Tampakakis E, Hibino N, Uosaki H, Kwon C. Miyamoto M, et al. Biochem Biophys Res Commun. 2021 Nov 5;577:12-16. doi: 10.1016/j.bbrc.2021.08.094. Epub 2021 Sep 2. Biochem Biophys Res Commun. 2021. PMID: 34487959 Free PMC article.
659 results