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Developmentally regulated stabilization of neuronal intermediate filaments in rat cerebral cortex.
Giasson BI, Mushynski WE. Giasson BI, et al. Among authors: mushynski we. Neurosci Lett. 1997 Jun 27;229(2):77-80. doi: 10.1016/s0304-3940(97)00425-4. Neurosci Lett. 1997. PMID: 9223595
Mitochondrial and axonal abnormalities precede disruption of the neurofilament network in a model of charcot-marie-tooth disease type 2E and are prevented by heat shock proteins in a mutant-specific fashion.
Tradewell ML, Durham HD, Mushynski WE, Gentil BJ. Tradewell ML, et al. Among authors: mushynski we. J Neuropathol Exp Neurol. 2009 Jun;68(6):642-52. doi: 10.1097/NEN.0b013e3181a5deeb. J Neuropathol Exp Neurol. 2009. PMID: 19458545
A neurotoxic peripherin splice variant in a mouse model of ALS.
Robertson J, Doroudchi MM, Nguyen MD, Durham HD, Strong MJ, Shaw G, Julien JP, Mushynski WE. Robertson J, et al. Among authors: mushynski we. J Cell Biol. 2003 Mar 17;160(6):939-49. doi: 10.1083/jcb.200205027. J Cell Biol. 2003. PMID: 12642616 Free PMC article.
Heterogeneity in the properties of NEFL mutants causing Charcot-Marie-Tooth disease results in differential effects on neurofilament assembly and susceptibility to intervention by the chaperone-inducer, celastrol.
Gentil BJ, Mushynski WE, Durham HD. Gentil BJ, et al. Among authors: mushynski we. Int J Biochem Cell Biol. 2013 Jul;45(7):1499-508. doi: 10.1016/j.biocel.2013.04.009. Epub 2013 Apr 22. Int J Biochem Cell Biol. 2013. PMID: 23618875
p38 Mitogen-activated protein kinase regulates myelination.
Haines JD, Fragoso G, Hossain S, Mushynski WE, Almazan G. Haines JD, et al. Among authors: mushynski we. J Mol Neurosci. 2008 May;35(1):23-33. doi: 10.1007/s12031-007-9011-0. Epub 2007 Nov 10. J Mol Neurosci. 2008. PMID: 17994198 Review.
Characterization of the cation-binding properties of porcine neurofilaments.
Lefebvre S, Mushynski WE. Lefebvre S, et al. Among authors: mushynski we. Biochemistry. 1988 Nov 1;27(22):8503-8. doi: 10.1021/bi00422a031. Biochemistry. 1988. PMID: 3149507
Heterodimeric associations between neuronal intermediate filament proteins.
Athlan ES, Mushynski WE. Athlan ES, et al. Among authors: mushynski we. J Biol Chem. 1997 Dec 5;272(49):31073-8. doi: 10.1074/jbc.272.49.31073. J Biol Chem. 1997. PMID: 9388258
Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit.
Giasson BI, Mushynski WE. Giasson BI, et al. Among authors: mushynski we. J Neurosci. 1997 Dec 15;17(24):9466-72. doi: 10.1523/JNEUROSCI.17-24-09466.1997. J Neurosci. 1997. PMID: 9391002 Free PMC article.
In a previous study (), we demonstrated a correlation between phosphorylation of perikaryal NFH and induction of stress-activated protein kinase (SAPK)-gamma. In this report, we present direct evidence showing that the in vivo activation of SAPKs by an upstream acti …
In a previous study (), we demonstrated a correlation between phosphorylation of perikaryal NFH and induction of stress-activated pro …
Apoptotic death of neurons exhibiting peripherin aggregates is mediated by the proinflammatory cytokine tumor necrosis factor-alpha.
Robertson J, Beaulieu JM, Doroudchi MM, Durham HD, Julien JP, Mushynski WE. Robertson J, et al. Among authors: mushynski we. J Cell Biol. 2001 Oct 15;155(2):217-26. doi: 10.1083/jcb.200107058. Epub 2001 Oct 15. J Cell Biol. 2001. PMID: 11604419 Free PMC article.
To further clarify the selectivity and mechanism of peripherin-induced neuronal death, we analyzed the effects of peripherin overexpression in primary neuronal cultures. ...
To further clarify the selectivity and mechanism of peripherin-induced neuronal death, we analyzed the effects of peripherin overexpr …
Inhibition of aberrant and constitutive phosphorylation of the high-molecular-mass neurofilament subunit by CEP-1347 (KT7515), an inhibitor of the stress-activated protein kinase signaling pathway.
O'Ferrall EK, Robertson J, Mushynski WE. O'Ferrall EK, et al. Among authors: mushynski we. J Neurochem. 2000 Dec;75(6):2358-67. doi: 10.1046/j.1471-4159.2000.0752358.x. J Neurochem. 2000. PMID: 11080187
We now present direct evidence for this involvement using CEP-1347, a specific inhibitor of SAPK activation. Inhibition by this drug of stress-induced phosphorylation of NFH and the middle-molecular-mass neurofilament subunit in the perikaryon of dorsal root ganglion (DRG)
We now present direct evidence for this involvement using CEP-1347, a specific inhibitor of SAPK activation. Inhibition by this drug
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