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Insulin resistance and improvements in signal transduction.
Musi N, Goodyear LJ. Musi N, et al. Endocrine. 2006 Feb;29(1):73-80. doi: 10.1385/ENDO:29:1:73. Endocrine. 2006. PMID: 16622294 Review.
A novel approach to reverse insulin resistance involves inhibition of the stress-activated protein kinase Jun N-terminal kinase (JNK) and the protein tyrosine phosphatases (PTPs). ...
A novel approach to reverse insulin resistance involves inhibition of the stress-activated protein kinase Jun N-terminal kinase (JNK) …
Pioglitazone is equally effective for diabetes prevention in older versus younger adults with impaired glucose tolerance.
Espinoza SE, Wang CP, Tripathy D, Clement SC, Schwenke DC, Banerji MA, Bray GA, Buchanan TA, Henry RR, Kitabchi AE, Mudaliar S, Stentz FB, Reaven PD, DeFronzo RA, Musi N. Espinoza SE, et al. Among authors: musi n. Age (Dordr). 2016 Dec;38(5-6):485-493. doi: 10.1007/s11357-016-9946-6. Epub 2016 Sep 1. Age (Dordr). 2016. PMID: 27585671 Free PMC article. Clinical Trial.
A novel insulin resistance index to monitor changes in insulin sensitivity and glucose tolerance: the ACT NOW study.
Tripathy D, Cobb JE, Gall W, Adam KP, George T, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Reaven PD, Musi N, Ferrannini E, DeFronzo RA. Tripathy D, et al. Among authors: musi n. J Clin Endocrinol Metab. 2015 May;100(5):1855-62. doi: 10.1210/jc.2014-3824. Epub 2015 Jan 20. J Clin Endocrinol Metab. 2015. PMID: 25603459 Free PMC article. Clinical Trial.
The disposition index does not reflect β-cell function in IGT subjects treated with pioglitazone.
DeFronzo RA, Tripathy D, Abdul-Ghani M, Musi N, Gastaldelli A. DeFronzo RA, et al. Among authors: musi n. J Clin Endocrinol Metab. 2014 Oct;99(10):3774-81. doi: 10.1210/jc.2014-1515. Epub 2014 Jun 17. J Clin Endocrinol Metab. 2014. PMID: 24937535 Clinical Trial.
Baseline adiponectin levels do not influence the response to pioglitazone in ACT NOW.
Tripathy D, Clement SC, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, DeFronzo RA. Tripathy D, et al. Among authors: musi n. Diabetes Care. 2014 Jun;37(6):1706-11. doi: 10.2337/dc13-1745. Epub 2014 Apr 4. Diabetes Care. 2014. PMID: 24705615 Free PMC article. Clinical Trial.
Prevention of diabetes with pioglitazone in ACT NOW: physiologic correlates.
Defronzo RA, Tripathy D, Schwenke DC, Banerji M, Bray GA, Buchanan TA, Clement SC, Gastaldelli A, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD; ACT NOW Study. Defronzo RA, et al. Among authors: musi n. Diabetes. 2013 Nov;62(11):3920-6. doi: 10.2337/db13-0265. Epub 2013 Jul 17. Diabetes. 2013. PMID: 23863810 Free PMC article. Clinical Trial.
DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease.
Chen H, Shen F, Sherban A, Nocon A, Li Y, Wang H, Xu MJ, Rui X, Han J, Jiang B, Lee D, Li N, Keyhani-Nejad F, Fan JG, Liu F, Kamat A, Musi N, Guarente L, Pacher P, Gao B, Zang M. Chen H, et al. Among authors: musi n. Hepatology. 2018 Aug;68(2):496-514. doi: 10.1002/hep.29849. Epub 2018 May 21. Hepatology. 2018. PMID: 29457836 Free PMC article.
SAD-A Promotes Glucose-Stimulated Insulin Secretion Through Phosphorylation and Inhibition of GDIα in Male Islet β Cells.
Nie J, Sun C, Chang Z, Musi N, Shi Y. Nie J, et al. Among authors: musi n. Endocrinology. 2018 Aug 1;159(8):3036-3047. doi: 10.1210/en.2017-03243. Endocrinology. 2018. PMID: 29873699 Free PMC article.
Rationale and Study Design of a Randomized Clinical Trial of Metformin to Prevent Frailty in Older Adults With Prediabetes.
Espinoza SE, Musi N, Wang CP, Michalek J, Orsak B, Romo T, Powers B, Conde A, Moris M, Bair-Kelps D, Li Y, Ganapathy V, Jergensen TE, Kelly LC, Jiwani R. Espinoza SE, et al. Among authors: musi n. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):102-109. doi: 10.1093/gerona/glz078. J Gerontol A Biol Sci Med Sci. 2020. PMID: 30888034 Free PMC article.
Short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subjects.
Reyna SM, Tantiwong P, Cersosimo E, Defronzo RA, Sriwijitkamol A, Musi N. Reyna SM, et al. Among authors: musi n. J Diabetes Res. 2013;2013:107805. doi: 10.1155/2013/107805. Epub 2013 Mar 13. J Diabetes Res. 2013. PMID: 23671849 Free PMC article.
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