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Mutational dynamics between primary and relapse neuroblastomas.
Schramm A, Köster J, Assenov Y, Althoff K, Peifer M, Mahlow E, Odersky A, Beisser D, Ernst C, Henssen AG, Stephan H, Schröder C, Heukamp L, Engesser A, Kahlert Y, Theissen J, Hero B, Roels F, Altmüller J, Nürnberg P, Astrahantseff K, Gloeckner C, De Preter K, Plass C, Lee S, Lode HN, Henrich KO, Gartlgruber M, Speleman F, Schmezer P, Westermann F, Rahmann S, Fischer M, Eggert A, Schulte JH. Schramm A, et al. Nat Genet. 2015 Aug;47(8):872-7. doi: 10.1038/ng.3349. Epub 2015 Jun 29. Nat Genet. 2015. PMID: 26121086
The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and reduced subclonal heterogeneity. ...Recurrent alterations at relapse included mutations in the putative CHD5 neuroblastoma
The mutational burden significantly increased in relapsing tumors, accompanied by altered mutational signatures and red …
Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastoma.
Goldsmith KC, Gross M, Peirce S, Luyindula D, Liu X, Vu A, Sliozberg M, Guo R, Zhao H, Reynolds CP, Hogarty MD. Goldsmith KC, et al. Cancer Res. 2012 May 15;72(10):2565-77. doi: 10.1158/0008-5472.CAN-11-3603. Cancer Res. 2012. PMID: 22589275 Free PMC article.
Neuroblastoma is a childhood tumor in which transient therapeutic responses are typically followed by recurrence with lethal chemoresistant disease. ...We found that viable neuroblastoma cells and primary tumors are primed for death with tonic sequestr
Neuroblastoma is a childhood tumor in which transient therapeutic responses are typically followed by recurrence with lethal c
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