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Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.
Procopiou PA, Barrett VJ, Bevan NJ, Biggadike K, Box PC, Butchers PR, Coe DM, Conroy R, Emmons A, Ford AJ, Holmes DS, Horsley H, Kerr F, Li-Kwai-Cheung AM, Looker BE, Mann IS, McLay IM, Morrison VS, Mutch PJ, Smith CE, Tomlin P. Procopiou PA, et al. Among authors: mutch pj. J Med Chem. 2010 Jun 10;53(11):4522-30. doi: 10.1021/jm100326d. J Med Chem. 2010. PMID: 20462258
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
Procopiou PA, Barrett VJ, Bevan NJ, Biggadike K, Butchers PR, Coe DM, Conroy R, Edney DD, Field RN, Ford AJ, Guntrip SB, Looker BE, McLay IM, Monteith MJ, Morrison VS, Mutch PJ, Richards SA, Sasse R, Smith CE. Procopiou PA, et al. Among authors: mutch pj. J Med Chem. 2009 Apr 23;52(8):2280-8. doi: 10.1021/jm801016j. J Med Chem. 2009. PMID: 19317397
The discovery of long-acting saligenin β₂ adrenergic receptor agonists incorporating hydantoin or uracil rings.
Procopiou PA, Barrett VJ, Bevan NJ, Butchers PR, Conroy R, Emmons A, Ford AJ, Jeulin S, Looker BE, Lunniss GE, Morrison VS, Mutch PJ, Perciaccante R, Ruston M, Smith CE, Somers G. Procopiou PA, et al. Among authors: mutch pj. Bioorg Med Chem. 2011 Jul 15;19(14):4192-201. doi: 10.1016/j.bmc.2011.05.064. Epub 2011 Jun 21. Bioorg Med Chem. 2011. PMID: 21696967
Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing.
Procopiou PA, Barrett VJ, Biggadike K, Butchers PR, Craven A, Ford AJ, Guntrip SB, Holmes DS, Hughes SC, Jones AE, Looker BE, Mutch PJ, Ruston M, Needham D, Smith CE. Procopiou PA, et al. Among authors: mutch pj. J Med Chem. 2014 Jan 9;57(1):159-70. doi: 10.1021/jm401532g. Epub 2013 Dec 20. J Med Chem. 2014. PMID: 24359185
Safety and Pharmacokinetics of Bendamustine Rapid-Infusion Formulation.
Cheung EM, Edenfield WJ, Mattar B, Anthony SP, Mutch PJ, Chanas B, Smith M, Hepner A. Cheung EM, et al. Among authors: mutch pj. J Clin Pharmacol. 2017 Nov;57(11):1400-1408. doi: 10.1002/jcph.942. Epub 2017 May 31. J Clin Pharmacol. 2017. PMID: 28561902 Clinical Trial.
Efficacy of Augmentation of Cognitive Behavior Therapy With Weight-Adjusted d-Cycloserine vs Placebo in Pediatric Obsessive-Compulsive Disorder: A Randomized Clinical Trial.
Storch EA, Wilhelm S, Sprich S, Henin A, Micco J, Small BJ, McGuire J, Mutch PJ, Lewin AB, Murphy TK, Geller DA. Storch EA, et al. Among authors: mutch pj. JAMA Psychiatry. 2016 Aug 1;73(8):779-88. doi: 10.1001/jamapsychiatry.2016.1128. JAMA Psychiatry. 2016. PMID: 27367832 Free PMC article. Clinical Trial.
Characterization of the pediatric acute-onset neuropsychiatric syndrome phenotype.
Murphy TK, Patel PD, McGuire JF, Kennel A, Mutch PJ, Parker-Athill EC, Hanks CE, Lewin AB, Storch EA, Toufexis MD, Dadlani GH, Rodriguez CA. Murphy TK, et al. Among authors: mutch pj. J Child Adolesc Psychopharmacol. 2015 Feb;25(1):14-25. doi: 10.1089/cap.2014.0062. Epub 2014 Oct 14. J Child Adolesc Psychopharmacol. 2015. PMID: 25314221 Free PMC article.
26 results