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Camelid single-domain antibody-fragment engineering for (pre)clinical in vivo molecular imaging applications: adjusting the bullet to its target.
De Vos J, Devoogdt N, Lahoutte T, Muyldermans S. De Vos J, et al. Expert Opin Biol Ther. 2013 Aug;13(8):1149-60. doi: 10.1517/14712598.2013.800478. Epub 2013 May 16. Expert Opin Biol Ther. 2013. PMID: 23675652 Review.
Naturally occurring antibodies devoid of light chains.
Hamers-Casterman C, Atarhouch T, Muyldermans S, Robinson G, Hamers C, Songa EB, Bendahman N, Hamers R. Hamers-Casterman C, et al. Nature. 1993 Jun 3;363(6428):446-8. doi: 10.1038/363446a0. Nature. 1993. PMID: 8502296
Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme.
Desmyter A, Transue TR, Ghahroudi MA, Thi MH, Poortmans F, Hamers R, Muyldermans S, Wyns L. Desmyter A, et al. Nat Struct Biol. 1996 Sep;3(9):803-11. doi: 10.1038/nsb0996-803. Nat Struct Biol. 1996. PMID: 8784355
Camel single-domain antibody inhibits enzyme by mimicking carbohydrate substrate.
Transue TR, De Genst E, Ghahroudi MA, Wyns L, Muyldermans S. Transue TR, et al. Proteins. 1998 Sep 1;32(4):515-22. doi: 10.1002/(sici)1097-0134(19980901)32:4<515::aid-prot9>;2-e. Proteins. 1998. PMID: 9726420
Isolation and characterization of single-chain Fv genes encoding antibodies specific for Drosophila Poxn protein.
Hassanzadeh GH G, De Silva KS, Dambly-Chaudière C, Brys L, Ghysen A, Hamers R, Muyldermans S, De Baetselier P. Hassanzadeh GH G, et al. FEBS Lett. 1998 Oct 16;437(1-2):75-80. doi: 10.1016/s0014-5793(98)01204-6. FEBS Lett. 1998. PMID: 9804175
A single-domain antibody fragment in complex with RNase A: non-canonical loop structures and nanomolar affinity using two CDR loops.
Decanniere K, Desmyter A, Lauwereys M, Ghahroudi MA, Muyldermans S, Wyns L. Decanniere K, et al. Structure. 1999 Apr 15;7(4):361-70. doi: 10.1016/s0969-2126(99)80049-5. Structure. 1999. PMID: 10196124
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