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The emerging roles of forkhead box (Fox) proteins in cancer.
Myatt SS, Lam EW. Myatt SS, et al. Nat Rev Cancer. 2007 Nov;7(11):847-59. doi: 10.1038/nrc2223. Nat Rev Cancer. 2007. PMID: 17943136 Review.
SUMOylation inhibits FOXM1 activity and delays mitotic transition.
Myatt SS, Kongsema M, Man CW, Kelly DJ, Gomes AR, Khongkow P, Karunarathna U, Zona S, Langer JK, Dunsby CW, Coombes RC, French PM, Brosens JJ, Lam EW. Myatt SS, et al. Oncogene. 2014 Aug 21;33(34):4316-29. doi: 10.1038/onc.2013.546. Epub 2013 Dec 23. Oncogene. 2014. PMID: 24362530 Free PMC article.
FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance.
Millour J, Constantinidou D, Stavropoulou AV, Wilson MS, Myatt SS, Kwok JM, Sivanandan K, Coombes RC, Medema RH, Hartman J, Lykkesfeldt AE, Lam EW. Millour J, et al. Among authors: myatt ss. Oncogene. 2010 May 20;29(20):2983-95. doi: 10.1038/onc.2010.47. Epub 2010 Mar 8. Oncogene. 2010. PMID: 20208560 Free PMC article.
Many forks in the path: cycling with FoxO.
Ho KK, Myatt SS, Lam EW. Ho KK, et al. Among authors: myatt ss. Oncogene. 2008 Apr 7;27(16):2300-11. doi: 10.1038/onc.2008.23. Oncogene. 2008. PMID: 18391972 Review.
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW. Peck B, et al. Among authors: myatt ss. Mol Cancer Ther. 2010 Apr;9(4):844-55. doi: 10.1158/1535-7163.MCT-09-0971. Epub 2010 Apr 6. Mol Cancer Ther. 2010. PMID: 20371709 Free article.
FOXM1 confers acquired cisplatin resistance in breast cancer cells.
Kwok JM, Peck B, Monteiro LJ, Schwenen HD, Millour J, Coombes RC, Myatt SS, Lam EW. Kwok JM, et al. Among authors: myatt ss. Mol Cancer Res. 2010 Jan;8(1):24-34. doi: 10.1158/1541-7786.MCR-09-0432. Epub 2010 Jan 12. Mol Cancer Res. 2010. PMID: 20068070 Free PMC article.
Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer.
Myatt SS, Wang J, Monteiro LJ, Christian M, Ho KK, Fusi L, Dina RE, Brosens JJ, Ghaem-Maghami S, Lam EW. Myatt SS, et al. Cancer Res. 2010 Jan 1;70(1):367-77. doi: 10.1158/0008-5472.CAN-09-1891. Epub 2009 Dec 22. Cancer Res. 2010. PMID: 20028871 Free PMC article.
The novel molecule 2-[5-(2-chloroethyl)-2-acetoxy-benzyl]-4-(2-chloroethyl)-phenyl acetate inhibits phosphoinositide 3-kinase/Akt/mammalian target of rapamycin signalling through JNK activation in cancer cells.
Ho KK, Rosivatz E, Gunn RM, Smith ME, Stavropoulou AV, Rosivatz E, Numbere MG, Wong JB, Lafitte VG, Behrendt JM, Myatt SS, Hailes HC, Woscholski R, Lam EW. Ho KK, et al. Among authors: myatt ss. FEBS J. 2009 Aug;276(15):4037-50. doi: 10.1111/j.1742-4658.2009.07112.x. Epub 2009 Jun 22. FEBS J. 2009. PMID: 19549188 Free article.
FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.
Francis RE, Myatt SS, Krol J, Hartman J, Peck B, McGovern UB, Wang J, Guest SK, Filipovic A, Gojis O, Palmieri C, Peston D, Shousha S, Yu Q, Sicinski P, Coombes RC, Lam EW. Francis RE, et al. Among authors: myatt ss. Int J Oncol. 2009 Jul;35(1):57-68. doi: 10.3892/ijo_00000313. Int J Oncol. 2009. PMID: 19513552 Free PMC article.
Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer.
McGovern UB, Francis RE, Peck B, Guest SK, Wang J, Myatt SS, Krol J, Kwok JM, Polychronis A, Coombes RC, Lam EW. McGovern UB, et al. Among authors: myatt ss. Mol Cancer Ther. 2009 Mar;8(3):582-91. doi: 10.1158/1535-7163.MCT-08-0805. Epub 2009 Mar 10. Mol Cancer Ther. 2009. PMID: 19276163 Free article.
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