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Myc regulates the transcription of the PRC2 gene to control the expression of developmental genes in embryonic stem cells.
Neri F, Zippo A, Krepelova A, Cherubini A, Rocchigiani M, Oliviero S. Neri F, et al. Mol Cell Biol. 2012 Feb;32(4):840-51. doi: 10.1128/MCB.06148-11. Epub 2011 Dec 19. Mol Cell Biol. 2012. PMID: 22184065 Free PMC article.
The silencing of both c-Myc and N-Myc in ESC results in reduced expression of PRC2 and H3K27me3 at Polycomb target developmental regulators and upregulation of genes involved in primitive endoderm differentiation. ...Thus, Myc proteins contro …
The silencing of both c-Myc and N-Myc in ESC results in reduced expression of PRC2 and H3K27me3 at Polycomb target deve …
MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase.
Kaur M, Cole MD. Kaur M, et al. Cancer Res. 2013 Jan 15;73(2):695-705. doi: 10.1158/0008-5472.CAN-12-2522. Epub 2012 Nov 7. Cancer Res. 2013. PMID: 23135913 Free PMC article.
MYC is a pleiotropic transcription factor that both activates and represses a broad range of target genes and is indispensable for cell growth. ...Importantly, expression of a phospho-defective EZH2 mutant is sufficient to recapitulate nearly half of all MYC- …
MYC is a pleiotropic transcription factor that both activates and represses a broad range of target genes and is indispensable …
ALK positively regulates MYCN activity through repression of HBP1 expression.
Claeys S, Denecker G, Durinck K, Decaesteker B, Mus LM, Loontiens S, Vanhauwaert S, Althoff K, Wigerup C, Bexell D, Dolman E, Henrich KO, Wehrmann L, Westerhout EM, Demoulin JB, Kumps C, Van Maerken T, Laureys G, Van Neste C, De Wilde B, De Wever O, Westermann F, Versteeg R, Molenaar JJ, Påhlman S, Schulte JH, De Preter K, Speleman F. Claeys S, et al. Oncogene. 2019 Apr;38(15):2690-2705. doi: 10.1038/s41388-018-0595-3. Epub 2018 Dec 11. Oncogene. 2019. PMID: 30538293
HBP1 inhibits both the transcriptional activating and repressing activity of MYCN, the latter being mediated through PRC2 activity. HBP1 itself is under negative control of MYCN through miR-17~92. Combined targeting of HBP1 by PI(3)K antagonists and MYCN sign …
HBP1 inhibits both the transcriptional activating and repressing activity of MYCN, the latter being mediated through PRC2 acti …
MYCN and the epigenome.
He S, Liu Z, Oh DY, Thiele CJ. He S, et al. Front Oncol. 2013 Jan 25;3:1. doi: 10.3389/fonc.2013.00001. eCollection 2013. Front Oncol. 2013. PMID: 23373009 Free PMC article.
Agents such as retinoic acid normalize the signaling pathways and impose growth control and induction of differentiation. Recent studies in embryonic stem cells indicate that polycomb repressor complex proteins (PRC1 and PRC2) play a major role in regulating …
Agents such as retinoic acid normalize the signaling pathways and impose growth control and induction of differentiation. Recent stud …
Expression of enhancer of zeste homolog 2 (EZH2) protein in histiocytic and dendritic cell neoplasms with evidence for p-ERK1/2-related, but not MYC- or p-STAT3-related cell signaling.
Tian X, Xu J, Fletcher C, Hornick JL, Dorfman DM. Tian X, et al. Mod Pathol. 2018 Apr;31(4):553-561. doi: 10.1038/modpathol.2017.174. Epub 2018 Jan 12. Mod Pathol. 2018. PMID: 29327713
EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which controls gene silencing through post-translational modification, and is overexpressed in various carcinomas and hematopoietic neoplasms. ...In cases …
EZH2 is an important enzymatic subunit of the epigenetic regulator polycomb repressive complex 2 (PRC2), which controls …
PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma.
Tsubota S, Kishida S, Shimamura T, Ohira M, Yamashita S, Cao D, Kiyonari S, Ushijima T, Kadomatsu K. Tsubota S, et al. Cancer Res. 2017 Oct 1;77(19):5259-5271. doi: 10.1158/0008-5472.CAN-16-3144. Epub 2017 Aug 14. Cancer Res. 2017. PMID: 28807939 Free article.
In clinical specimens, expression of MYC and PRC2 target genes correlated strongly and predicted survival outcomes. Together, our findings highlighted PRC2-mediated transcriptional control during embryogenesis as a critical step in the developme …
In clinical specimens, expression of MYC and PRC2 target genes correlated strongly and predicted survival outcomes. Together, …
Fuse-binding protein 1 is a target of the EZH2 inhibitor GSK343, in osteosarcoma cells.
Xiong X, Zhang J, Liang W, Cao W, Qin S, Dai L, Ye D, Liu Z. Xiong X, et al. Int J Oncol. 2016 Aug;49(2):623-8. doi: 10.3892/ijo.2016.3541. Epub 2016 May 27. Int J Oncol. 2016. PMID: 27278257
EZH2 impairs gene expression by catalyzing the tri-methylation of histone H3 lysine 27 (H3K27me3) which controls gene transcription epigenetically. It is reported that EZH2 expression is higher in osteosarcoma than in osteoblastoma and the highest expression of EZH2 …
EZH2 impairs gene expression by catalyzing the tri-methylation of histone H3 lysine 27 (H3K27me3) which controls gene transcriptio …
Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning.
Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, Jiang H, Lu B, Yates J 3rd, Liu C, Zhao K, Zheng Y. Jia J, et al. Cell. 2012 Oct 26;151(3):576-89. doi: 10.1016/j.cell.2012.09.023. Cell. 2012. PMID: 23101626 Free PMC article.
Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various transcription factors and chromatin-modifying enzymes. ...The mRNA degradation function also ensures rapid cell proliferation by blockin …
Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various …