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S100A8 and S100A9 in inflammation and cancer.
Gebhardt C, Németh J, Angel P, Hess J. Gebhardt C, et al. Among authors: nemeth j. Biochem Pharmacol. 2006 Nov 30;72(11):1622-31. doi: 10.1016/j.bcp.2006.05.017. Epub 2006 Jul 17. Biochem Pharmacol. 2006. PMID: 16846592 Review.
Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice.
Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P. Pusterla T, et al. Among authors: nemeth j. Hepatology. 2013 Jul;58(1):363-73. doi: 10.1002/hep.26395. Hepatology. 2013. PMID: 23504974
Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment.
Wiechert L, Németh J, Pusterla T, Bauer C, De Ponti A, Manthey S, Marhenke S, Vogel A, Klingmüller U, Hess J, Angel P. Wiechert L, et al. Among authors: nemeth j. Cell Commun Signal. 2012 Dec 15;10(1):40. doi: 10.1186/1478-811X-10-40. Cell Commun Signal. 2012. PMID: 23241281 Free PMC article.
Identification of the Rage-dependent gene regulatory network in a mouse model of skin inflammation.
Riehl A, Bauer T, Brors B, Busch H, Mark R, Németh J, Gebhardt C, Bierhaus A, Nawroth P, Eils R, König R, Angel P, Hess J. Riehl A, et al. Among authors: nemeth j. BMC Genomics. 2010 Oct 5;11:537. doi: 10.1186/1471-2164-11-537. BMC Genomics. 2010. PMID: 20923549 Free PMC article.
S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis.
Németh J, Stein I, Haag D, Riehl A, Longerich T, Horwitz E, Breuhahn K, Gebhardt C, Schirmacher P, Hahn M, Ben-Neriah Y, Pikarsky E, Angel P, Hess J. Németh J, et al. Hepatology. 2009 Oct;50(4):1251-62. doi: 10.1002/hep.23099. Hepatology. 2009. PMID: 19670424
The receptor RAGE: Bridging inflammation and cancer.
Riehl A, Németh J, Angel P, Hess J. Riehl A, et al. Among authors: nemeth j. Cell Commun Signal. 2009 May 8;7:12. doi: 10.1186/1478-811X-7-12. Cell Commun Signal. 2009. PMID: 19426472 Free PMC article.
RAGE signaling sustains inflammation and promotes tumor development.
Gebhardt C, Riehl A, Durchdewald M, Németh J, Fürstenberger G, Müller-Decker K, Enk A, Arnold B, Bierhaus A, Nawroth PP, Hess J, Angel P. Gebhardt C, et al. Among authors: nemeth j. J Exp Med. 2008 Feb 18;205(2):275-85. doi: 10.1084/jem.20070679. Epub 2008 Jan 21. J Exp Med. 2008. PMID: 18208974 Free PMC article.
Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.
Horwitz E, Stein I, Andreozzi M, Nemeth J, Shoham A, Pappo O, Schweitzer N, Tornillo L, Kanarek N, Quagliata L, Zreik F, Porat RM, Finkelstein R, Reuter H, Koschny R, Ganten T, Mogler C, Shibolet O, Hess J, Breuhahn K, Grunewald M, Schirmacher P, Vogel A, Terracciano L, Angel P, Ben-Neriah Y, Pikarsky E. Horwitz E, et al. Among authors: nemeth j. Cancer Discov. 2014 Jun;4(6):730-43. doi: 10.1158/2159-8290.CD-13-0782. Epub 2014 Mar 31. Cancer Discov. 2014. PMID: 24687604
Restoration of membrane TNF-like activity by cell surface targeting and matrix metalloproteinase-mediated processing of a TNF prodrug.
Gerspach J, Müller D, Münkel S, Selchow O, Nemeth J, Noack M, Petrul H, Menrad A, Wajant H, Pfizenmaier K. Gerspach J, et al. Among authors: nemeth j. Cell Death Differ. 2006 Feb;13(2):273-84. doi: 10.1038/sj.cdd.4401735. Cell Death Differ. 2006. PMID: 16052236
Target-selective activation of a TNF prodrug by urokinase-type plasminogen activator (uPA) mediated proteolytic processing at the cell surface.
Gerspach J, Németh J, Münkel S, Wajant H, Pfizenmaier K. Gerspach J, et al. Among authors: nemeth j. Cancer Immunol Immunother. 2006 Dec;55(12):1590-600. doi: 10.1007/s00262-006-0162-6. Epub 2006 Apr 25. Cancer Immunol Immunother. 2006. PMID: 16636812
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