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1986 2
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190 results

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Page 1
N-glycoproteomics of brain synapses and synaptic vesicles.
Bradberry MM, Peters-Clarke TM, Shishkova E, Chapman ER, Coon JJ. Bradberry MM, et al. Cell Rep. 2023 Apr 25;42(4):112368. doi: 10.1016/j.celrep.2023.112368. Epub 2023 Apr 9. Cell Rep. 2023. PMID: 37036808 Free PMC article.
At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the major SV glycoproteins synaptophysin and SV2A to SVs. Despite this key role for …
At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for robust neurotransmission. Asparagine (N) …
Structure of a human synaptic GABA(A) receptor.
Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE. Zhu S, et al. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27. Nature. 2018. PMID: 29950725 Free PMC article.
Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (gamma-aminobutyric acid) and its synaptic target, the type A GABA receptor (GABA(A) receptor). ...Here we present high-resolution cryo-electron microscopy structures …
Fast inhibitory neurotransmission in the brain is principally mediated by the neurotransmitter GABA (gamma-aminobutyric acid) and its …
Comprehensive and Site-Specific Characterization of Protein N-Glycosylation in AD Samples Reveals Its Potential Roles in Protein Aggregation and Synaptic Dysfunction.
Xu X, Tan H, Yin K, Xu S, Wang Z, Serrano GE, Beach TG, Wang X, Peng J, Wu R. Xu X, et al. Anal Chem. 2025 Oct 14;97(40):21873-21882. doi: 10.1021/acs.analchem.5c02455. Epub 2025 Oct 3. Anal Chem. 2025. PMID: 41042700 Free PMC article.
Additionally, downregulated N-glycosylation sites were enriched in synaptic membrane proteins, such as Ca(2+) ion channels, GABA-gated chloride channels, and glutamate receptors, implicating glycosylation loss in synaptic dysfunction. Our …
Additionally, downregulated N-glycosylation sites were enriched in synaptic membrane proteins, such as Ca(2+) io …
Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.
Benner O, Cast TP, Minamide LS, Lenninger Z, Bamburg JR, Chanda S. Benner O, et al. J Biol Chem. 2023 Dec;299(12):105361. doi: 10.1016/j.jbc.2023.105361. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865312 Free PMC article.
We found that endogenous NLGN proteins are differentially glycosylated across several regions of murine brain in a sex-independent but isoform-dependent manner. ...Therefore, our results highlight an essential mechanistic contribution of N-linked gl …
We found that endogenous NLGN proteins are differentially glycosylated across several regions of murine brain in a sex- …
Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease.
Zhang Q, Ma C, Chin LS, Li L. Zhang Q, et al. Sci Adv. 2020 Oct 2;6(40):eabc5802. doi: 10.1126/sciadv.abc5802. Print 2020 Oct. Sci Adv. 2020. PMID: 33008897 Free PMC article.
Protein N-glycosylation plays critical roles in controlling brain function, but little is known about human brain N-glycoproteome and its alterations in Alzheimer's disease (AD). ...The study provided a system-level view of human brain …
Protein N-glycosylation plays critical roles in controlling brain function, but little is known about human b …
Neuronal activity-driven O-GlcNAcylation promotes mitochondrial plasticity.
Yu SB, Wang H, Sanchez RG, Carlson NM, Nguyen K, Zhang A, Papich ZD, Abushawish AA, Whiddon Z, Matysik W, Zhang J, Whisenant TC, Ghassemian M, Koberstein JN, Stewart ML, Myers SA, Pekkurnaz G. Yu SB, et al. Dev Cell. 2024 Aug 19;59(16):2143-2157.e9. doi: 10.1016/j.devcel.2024.05.008. Epub 2024 Jun 5. Dev Cell. 2024. PMID: 38843836 Free PMC article.
Here, we demonstrate that the metabolic sensor enzyme O-linked N-acetyl glucosamine (O-GlcNAc) transferase regulates neuronal activity-driven mitochondrial bioenergetics in hippocampal and cortical neurons. ...Mitochondrial O-GlcNAcylation is promoted by activity-driven gl …
Here, we demonstrate that the metabolic sensor enzyme O-linked N-acetyl glucosamine (O-GlcNAc) transferase regulates neuronal activit …
The emerging landscape of brain glycosylation: from molecular complexity to therapeutic potential.
Seo Y, Park JE, Yu JY, Lee B, Yoon JH, An HJ. Seo Y, et al. Exp Mol Med. 2025 Oct;57(10):2214-2225. doi: 10.1038/s12276-025-01560-8. Epub 2025 Oct 14. Exp Mol Med. 2025. PMID: 41087652 Free PMC article. Review.
Although glycans constitute less than 1% of the brain's mass, their impact is disproportionately profound. Recent technological advances have uncovered the essential contributions of both protein- and lipid-bound glycans, including N-glycans, O-glycans …
Although glycans constitute less than 1% of the brain's mass, their impact is disproportionately profound. Recent technologica …
N-Glycosylation in isolated rat nerve terminals.
Matthies I, Abrahams JL, Jensen P, Oliveira T, Kolarich D, Larsen MR. Matthies I, et al. Mol Omics. 2021 Aug 1;17(4):517-532. doi: 10.1039/d0mo00044b. Epub 2021 Jun 9. Mol Omics. 2021. PMID: 34106099
N-linked glycosylation is a ubiquitous protein modification that is capable of modulating protein structure, function and interactions. Many proteins in the brain associated with the synapse and important for synaptic transmission …
N-linked glycosylation is a ubiquitous protein modification that is capable of modulating protein structure, fun …
RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.
Wang J, Miao Y, Wicklein R, Sun Z, Wang J, Jude KM, Fernandes RA, Merrill SA, Wernig M, Garcia KC, Südhof TC. Wang J, et al. Cell. 2021 Nov 24;184(24):5869-5885.e25. doi: 10.1016/j.cell.2021.10.016. Epub 2021 Nov 9. Cell. 2021. PMID: 34758294 Free PMC article.
RTN4-binding proteins were widely studied as "NoGo" receptors, but their physiological interactors and roles remain elusive. ...Thus, BAI binding to RTN4/NoGo receptors represents a receptor-ligand axis that, enabled by rare post-translational modifications, controls devel …
RTN4-binding proteins were widely studied as "NoGo" receptors, but their physiological interactors and roles remain elusive. ...Thus, …
O-GlcNAcylation in health and neurodegenerative diseases.
Lee BE, Suh PG, Kim JI. Lee BE, et al. Exp Mol Med. 2021 Nov;53(11):1674-1682. doi: 10.1038/s12276-021-00709-5. Epub 2021 Nov 26. Exp Mol Med. 2021. PMID: 34837015 Free PMC article. Review.
O-GlcNAcylation is a posttranslational modification that adds O-linked beta-N-acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein modification interacts with key cellular pathways involved in transcription, translation, …
O-GlcNAcylation is a posttranslational modification that adds O-linked beta-N-acetylglucosamine (O-GlcNAc) to serine or threonine res …
190 results